Mouse Genome Informatics
hm
    Ptpn11tm1Rbn/Ptpn11tm1Rbn
involves: 129 * Black Swiss
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• homozygotes die prior to E10.5; at this stage, 44% of mutant embryos are resorbed

reproductive system
• litter size from heterozygous breeding pairs averages 6.2 2.0 relative to 10.8 2.0 for heterozygous male wild-type female crosses

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Noonan Syndrome 1; NS1 163950 J:35137