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Phenotypes Associated with This Genotype
Genotype
MGI:2176527
Allelic
Composition
Ptpn11tm1Rbn/Ptpn11tm1Rbn
Genetic
Background
involves: 129 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1Rbn mutation (0 available); any Ptpn11 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die prior to E10.5; at this stage, 44% of mutant embryos are resorbed

reproductive system
• litter size from heterozygous breeding pairs averages 6.2 2.0 relative to 10.8 2.0 for heterozygous male wild-type female crosses

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Noonan Syndrome 1; NS1 163950 J:35137


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory