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Phenotypes Associated with This Genotype
Genotype
MGI:2176483
Allelic
Composition
Fgfr2tm2.3Dsn/Fgfr2+
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm2.3Dsn mutation (0 available); any Fgfr2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Percocious ossification of coronal sutures and the sternum in Fgfr2tm2.3Dsn/Fgfr2+ mice

mortality/aging
• mice died within 9 days of birth (J:72517)
• mice died within 9 days of birth (J:72517)

craniofacial
• rounded skull with dorso ventral extension of the cranium (J:72517)
• rounded skull with dorso ventral extension of the cranium (J:72517)
• zygomatic arch bones were fused at their joints (J:72517)
• zygomatic arch bones were fused at their joints (J:72517)
• associated with the premature coronal suture fusion (J:72517)
• associated with the premature coronal suture fusion (J:72517)

digestive/alimentary system
N
• normal stomach and gut architecture and innervation (J:72517)
• normal stomach and gut architecture and innervation (J:72517)

endocrine/exocrine glands
N
• adrenal glands were of normal size (J:72517)
• adrenal glands were of normal size (J:72517)
• P1 mutants show a lack of exorbital lacrimal gland development (J:72517)
• P1 mutants show a lack of exorbital lacrimal gland development (J:72517)

growth/size/body
• 90% are slightly smaller at birth (J:72517)
• 90% are slightly smaller at birth (J:72517)
• mutants do not gain weight after birth and die within 9 days (J:72517)
• mutants do not gain weight after birth and die within 9 days (J:72517)

homeostasis/metabolism
• putatively due to malnutrition resulting from a gastrointestinal defect (J:72517)
• putatively due to malnutrition resulting from a gastrointestinal defect (J:72517)

liver/biliary system
• mild lobulation defect (J:72517)
• mild lobulation defect (J:72517)

renal/urinary system
• fewer glomeruli relative to wild-type (J:72517)
• fewer glomeruli relative to wild-type (J:72517)
• fewer and degenerating glomeruli are seen at P2 (J:72517)
• fewer and degenerating glomeruli are seen at P2 (J:72517)
• kidneys did not grow beyond their birth size (J:72517)
• kidneys did not grow beyond their birth size (J:72517)
• fewer developing nephrons in the cortical region at E14.5 (J:72517)
• fewer developing nephrons in the cortical region at E14.5 (J:72517)
• distal tubules are dilated (J:72517)
• distal tubules are dilated (J:72517)
• proximal tubules are dilated (J:72517)
• proximal tubules are dilated (J:72517)

respiratory system
• lung mesenchyme is more compact and often congested with red blood cells at P1 (J:72517)
• lung mesenchyme is more compact and often congested with red blood cells at P1 (J:72517)
• incomplete aveolarization (J:72517)
• incomplete aveolarization (J:72517)
• partial lobulation of the right lung (J:72517)
• partial lobulation of the right lung (J:72517)
• fewer bronchioles lined with ciliated cells and fewer branched alveolar structures (J:72517)
• fewer bronchioles lined with ciliated cells and fewer branched alveolar structures (J:72517)
• development of fewer bronchioles lined with ciliated cells (J:72517)
• development of fewer bronchioles lined with ciliated cells (J:72517)
• three partially separated pulmonary lobes rather than the four observed in wild-type (J:72517)
• three partially separated pulmonary lobes rather than the four observed in wild-type (J:72517)

skeleton
• rounded skull with dorso ventral extension of the cranium (J:72517)
• rounded skull with dorso ventral extension of the cranium (J:72517)
• zygomatic arch bones were fused at their joints (J:72517)
• zygomatic arch bones were fused at their joints (J:72517)
• associated with the premature coronal suture fusion (J:72517)
• associated with the premature coronal suture fusion (J:72517)
• individual sternebrae are thicker and less congruent (J:72517)
• individual sternebrae are thicker and less congruent (J:72517)
• manubrium is bifurcated (J:72517)
• manubrium is bifurcated (J:72517)
• abnormal ossification of the intersternebral cartilage, first observed at E16.5 (J:72517)
• abnormal ossification of the intersternebral cartilage, first observed at E16.5 (J:72517)
• ossification of the coronal sutures by E18 (J:72517)
• ossification of the coronal sutures by E18 (J:72517)

vision/eye
• P1 mutants show a lack of exorbital lacrimal gland development (J:72517)
• P1 mutants show a lack of exorbital lacrimal gland development (J:72517)
• due to shallow orbits resulting from zygomatic bone abnormalities (J:72517)
• due to shallow orbits resulting from zygomatic bone abnormalities (J:72517)

Mouse Models of Human Disease
OMIM ID Ref(s)
Apert Syndrome 101200 J:72517
Pfeiffer Syndrome 101600 J:72517


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory