Mouse Genome Informatics
hm
    Cdkn2atm1Rdp/Cdkn2atm1Rdp
involves: 129/Sv * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• contains numerous megakaryocytes and lymphoblasts
• proliferative expansion of white pulp at 2 months of age

hematopoietic system
• abnormal extramedullary hematopoiesis becoming more severe with age
• occurs in nonlymphoid tissue such as the liver in addition to lymphoid tissue
• contains numerous megakaryocytes and lymphoblasts
• proliferative expansion of white pulp at 2 months of age

cellular
• size of "S" phase population of MEFs in culture is increased
• MEFs in culture grow more rapidly and achieve higher densities

tumorigenesis
• 69% of mice develop spontaneous tumors by 29 weeks of age whereas controls are free of tumors at 36 weeks
• average latency for tumor formation in 2 stage cancer induction is 9 weeks
• 4 of 14 mice develop cutaneous melanomas within 12 months of birth

integument
• 4 of 14 mice develop cutaneous melanomas within 12 months of birth

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Melanoma, Cutaneous Malignant, Susceptibility to, 2; CMM2 155601 J:53805