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Phenotypes Associated with This Genotype
Genotype
MGI:2175771
Allelic
Composition
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic
Background
involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (5 available); any Cdkn2a mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• contains numerous megakaryocytes and lymphoblasts (J:53805)
• contains numerous megakaryocytes and lymphoblasts (J:53805)
• proliferative expansion of white pulp at 2 months of age (J:53805)
• proliferative expansion of white pulp at 2 months of age (J:53805)

hematopoietic system
• abnormal extramedullary hematopoiesis becoming more severe with age (J:53805)
• occurs in nonlymphoid tissue such as the liver in addition to lymphoid tissue (J:53805)
• abnormal extramedullary hematopoiesis becoming more severe with age (J:53805)
• occurs in nonlymphoid tissue such as the liver in addition to lymphoid tissue (J:53805)
• contains numerous megakaryocytes and lymphoblasts (J:53805)
• contains numerous megakaryocytes and lymphoblasts (J:53805)
• proliferative expansion of white pulp at 2 months of age (J:53805)
• proliferative expansion of white pulp at 2 months of age (J:53805)

cellular
• size of "S" phase population of MEFs in culture is increased (J:53805)
• size of "S" phase population of MEFs in culture is increased (J:53805)
• MEFs in culture grow more rapidly and achieve higher densities (J:53805)
• MEFs in culture grow more rapidly and achieve higher densities (J:53805)

tumorigenesis
• 69% of mice develop spontaneous tumors by 29 weeks of age whereas controls are free of tumors at 36 weeks (J:53805)
• average latency for tumor formation in 2 stage cancer induction is 9 weeks (J:53805)
• 69% of mice develop spontaneous tumors by 29 weeks of age whereas controls are free of tumors at 36 weeks (J:53805)
• average latency for tumor formation in 2 stage cancer induction is 9 weeks (J:53805)
• 4 of 14 mice develop cutaneous melanomas within 12 months of birth (J:98545)
• 4 of 14 mice develop cutaneous melanomas within 12 months of birth (J:98545)
• angiosarcomas (J:53805)
• angiosarcomas (J:53805)

integument
• 4 of 14 mice develop cutaneous melanomas within 12 months of birth (J:98545)
• 4 of 14 mice develop cutaneous melanomas within 12 months of birth (J:98545)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Melanoma, Cutaneous Malignant, Susceptibility to, 2; CMM2 155601 J:53805


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory