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Phenotypes Associated with This Genotype
Genotype
MGI:2175729
Allelic
Composition
Car2n/Car2n
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Morphological changes in the stomach and intestine of Car2n/Car2n and Car9tm1Spas/Car9tm1Spas mice

renal/urinary system
• urine has a more alkaline pH than wild-type when given tap water to drink

growth/size/body
• smaller than controls starting not later than at 2 weeks of age

homeostasis/metabolism
• respiratory acidosis
• urine has a more alkaline pH than wild-type when given tap water to drink

skeleton
N
• the prominent osteopetrosis found in humans with carbonic anhydrase II deficiency syndrome could not be detected in mice aged up to 15 months

digestive/alimentary system
• some mutants exhibit intraepithelial lymphocytes in the duodenum
• 50% of mutants exhibit mild gastric pit-cell hyperplasia
• 13% of mutants exhibit gastric cysts
• bicarbonate secretory response of the duodenum to prostaglandin E2 (PGE2) is completely absent in mutants, however basal duodenal bicarbonate secretion is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory