Mouse Genome Informatics
hm
    Car2n/Car2n
involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Morphological changes in the stomach and intestine of Car2n/Car2n and Car9tm1Spas/Car9tm1Spas mice

renal/urinary system
• urine has a more alkaline pH than wild-type when given tap water to drink

growth/size
• smaller than controls starting not later than at 2 weeks of age

homeostasis/metabolism
• respiratory acidosis
• urine has a more alkaline pH than wild-type when given tap water to drink

skeleton
N
• the prominent osteopetrosis found in humans with carbonic anhydrase II deficiency syndrome could not be detected in mice aged up to 15 months (J:19268)

digestive/alimentary system
• some mutants exhibit intraepithelial lymphocytes in the duodenum
• 50% of mutants exhibit mild gastric pit-cell hyperplasia
• 13% of mutants exhibit gastric cysts
• bicarbonate secretory response of the duodenum to prostaglandin E2 (PGE2) is completely absent in mutants, however basal duodenal bicarbonate secretion is normal

Mouse Models of Human Disease
OMIM IDRef(s)
Osteopetrosis, Autosomal Recessive 3; OPTB3 259730 J:19268