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Phenotypes Associated with This Genotype
Genotype
MGI:2175729
Allelic
Composition
Car2n/Car2n
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Morphological changes in the stomach and intestine of Car2n/Car2n and Car9tm1Spas/Car9tm1Spas mice

renal/urinary system
• urine has a more alkaline pH than wild-type when given tap water to drink

growth/size/body
• smaller than controls starting not later than at 2 weeks of age

homeostasis/metabolism
• respiratory acidosis
• urine has a more alkaline pH than wild-type when given tap water to drink

skeleton
N
• the prominent osteopetrosis found in humans with carbonic anhydrase II deficiency syndrome could not be detected in mice aged up to 15 months

digestive/alimentary system
• some mutants exhibit intraepithelial lymphocytes in the duodenum
• 50% of mutants exhibit mild gastric pit-cell hyperplasia
• 13% of mutants exhibit gastric cysts
• bicarbonate secretory response of the duodenum to prostaglandin E2 (PGE2) is completely absent in mutants, however basal duodenal bicarbonate secretion is normal

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteopetrosis, Autosomal Recessive 3; OPTB3 259730 J:19268


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory