Mouse Genome Informatics
involves: 129X1/SvJ * C57BL/6
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• ionizing radiation fails to induce cell death; irradiation-induced cell death is almost absent in the hippocampal dentate gyrus, cerebellum, and cerebral cortex compared to wild-type
• only occasional dead cells are found in the external granule layer of the cerebellum whereas widespread cell death is observed in wild-type after irradiation
• in the retina no apoptosis is seen in the center of the retina compared to wild-type, but apoptosis occurs in the periphery of the irradiated retina of mutant and wild-type mice
• cell death in the subventricular zone after irradiation is present but reduced compared to wild-type

reproductive system
• mice are sterile

• mice are prone to lymphoma

Mouse Models of Human Disease
Ataxia-Telangiectasia; AT 208900 J:47752