Phenotypes Associated with This Genotype

Genotype
MGI:2175209

• Allelic Composition: Pax6^tm1Pgr/Pax6^tm1Pgr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:40439 )

• animals die shortly after birth

nervous system

absent olfactory bulb ( J:40439 )

vision/eye

anophthalmia ( J:40439 )

endocrine/exocrine glands

absent pancreatic alpha cells ( J:40439 )

• absence is suggested by the absence of glucagon-producing cells in the exocrine pancreas

disorganized pancreatic islets ( J:40439 )

• cells fail to form distinct islets and remained disorganized through the pancreatic exocrine tissue

• endocrine cells normally found at the periphery of islets are seen mixed with beta cells