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Phenotypes Associated with This Genotype
Genotype
MGI:2175204
Allelic
Composition
Pax6Sey-Dey/Pax6+
Genetic
Background
C3H/HeJ-Pax6Sey-Dey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6Sey-Dey mutation (1 available); any Pax6 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 5% of mice die 8 to 10 hours after birth (J:6072)
• 5% of mice die 8 to 10 hours after birth (J:6072)

vision/eye
• mice exhibit a partial or complete lose of iris tissue (J:6072)
• mice have an eye phenotype similar to aniridia (J:6072)
• mice exhibit a partial or complete lose of iris tissue (J:6072)
• mice have an eye phenotype similar to aniridia (J:6072)
• lens pit development is delayed by 1 to 2 days relative to in wild-type mice (J:6072)
• lens pit development is delayed by 1 to 2 days relative to in wild-type mice (J:6072)
• lens have anterior cataracts (J:6072)
• lens have anterior cataracts (J:6072)
• lens are small or absent (J:6072)
• lens are small or absent (J:6072)
• coloboma is visible by 11 days of gestation (J:6072)
• coloboma is visible by 11 days of gestation (J:6072)
• mice have small eyes that are half the size of normal eyes (J:6072)
• the anterior chamber of the eye is missing (J:6072)
• mice have small eyes that are half the size of normal eyes (J:6072)
• the anterior chamber of the eye is missing (J:6072)
• the retina is abnormally folded (J:6072)
• the retina is abnormally folded (J:6072)
• mice have a reduced retinal pigment layer (J:6072)
• mice have a reduced retinal pigment layer (J:6072)

nervous system
• at day 7 to 8 of gestation 2 embryos were found with exencephaly (J:6072)
• at day 7 to 8 of gestation 2 embryos were found with exencephaly (J:6072)

pigmentation
• mice have a white spot on their sternum that extends into a belt in some mice (J:6072)
• mice have a white spot on their sternum that extends into a belt in some mice (J:6072)
• mice have a reduced retinal pigment layer (J:6072)
• mice have a reduced retinal pigment layer (J:6072)
• mice have reduced pigmentation on their feet and tails (J:6072)
• mice have reduced pigmentation on their feet and tails (J:6072)

growth/size/body
• mice are 10 to 20% smaller in size than wild-type mice (J:6072)
• mice are 10 to 20% smaller in size than wild-type mice (J:6072)
• mice are smaller than wild-type mice before birth and remain so the rest of their lives (J:6072)
• mice are smaller than wild-type mice before birth and remain so the rest of their lives (J:6072)

tumorigenesis
N
• despite the loss of Wt1, no abnormal tumors are detected in mice (J:10820)
• despite the loss of Wt1, no abnormal tumors are detected in mice (J:10820)

renal/urinary system
N
• mice have normal urogenital organs (J:10820)
• mice have normal urogenital organs (J:10820)

integument
• mice have a white spot on their sternum that extends into a belt in some mice (J:6072)
• mice have a white spot on their sternum that extends into a belt in some mice (J:6072)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory