Mouse Genome Informatics
ht
    Pax6Sey-Dey/Pax6+
C3H/HeJ-Pax6Sey-Dey
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 5% of mice die 8 to 10 hours after birth

vision/eye
• mice exhibit a partial or complete lose of iris tissue
• mice have an eye phenotype similar to aniridia
• lens pit development is delayed by 1 to 2 days relative to in wild-type mice
• lens have anterior cataracts
• lens are small or absent
• coloboma is visible by 11 days of gestation
• mice have small eyes that are half the size of normal eyes
• the anterior chamber of the eye is missing
• the retina is abnormally folded
• mice have a reduced retinal pigment layer

nervous system
• at day 7 to 8 of gestation 2 embryos were found with exencephaly

pigmentation
• mice have a white spot on their sternum that extends into a belt in some mice
• mice have a reduced retinal pigment layer
• mice have reduced pigmentation on their feet and tails

growth/size/body
• mice are 10 to 20% smaller in size than wild-type mice
• mice are smaller than wild-type mice before birth and remain so the rest of their lives

tumorigenesis
N
• despite the loss of Wt1, no abnormal tumors are detected in mice (J:10820)

renal/urinary system
N
• mice have normal urogenital organs (J:10820)

integument
• mice have a white spot on their sternum that extends into a belt in some mice

Mouse Models of Human Disease
OMIM IDRef(s)
Aniridia; AN 106210 J:10820
NOT Peters Anomaly 604229 J:10820
NOT Wilms Tumor, Aniridia, Genitourinary Anomalies, and Mental Retardation Syndrome; WAGR 194072 J:10820