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Phenotypes Associated with This Genotype
Genotype
MGI:2175204
Allelic
Composition
Pax6Sey-Dey/Pax6+
Genetic
Background
C3H/HeJ-Pax6Sey-Dey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6Sey-Dey mutation (1 available); any Pax6 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 5% of mice die 8 to 10 hours after birth

vision/eye
• mice exhibit a partial or complete lose of iris tissue
• mice have an eye phenotype similar to aniridia
• lens pit development is delayed by 1 to 2 days relative to in wild-type mice
• lens have anterior cataracts
• lens are small or absent
• coloboma is visible by 11 days of gestation
• mice have small eyes that are half the size of normal eyes
• the anterior chamber of the eye is missing
• the retina is abnormally folded
• mice have a reduced retinal pigment layer

nervous system
• at day 7 to 8 of gestation 2 embryos were found with exencephaly

pigmentation
• mice have a white spot on their sternum that extends into a belt in some mice
• mice have a reduced retinal pigment layer
• mice have reduced pigmentation on their feet and tails

growth/size/body
• mice are 10 to 20% smaller in size than wild-type mice
• mice are smaller than wild-type mice before birth and remain so the rest of their lives

neoplasm
N
• despite the loss of Wt1, no abnormal tumors are detected in mice

renal/urinary system
N
• mice have normal urogenital organs

integument
• mice have a white spot on their sternum that extends into a belt in some mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory