Phenotypes Associated with This Genotype

Genotype
MGI:2175169

• Allelic Composition: Nrg1^tm1Leth/Nrg1^tm1Leth
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:33038 )

• under resorption at E11.5

cardiovascular system

trabecula carnea hypoplasia ( J:33038 )

• severly impaired formation; lack of intertrabecular sinusiods was noted

abnormal atrioventricular cushion morphology ( J:33038 )

• less contracted appearance in mutant embryos

dilated heart ventricle ( J:33038 )

• dilated common ventricle at E10.5 before septation occurs

decreased cardiac output ( J:33038 )

• decreased emptying of the common ventricle was observed at E10.5

decreased cardiac muscle contractility ( J:33038 )

• depressed contractility was observed

decreased heart rate ( J:33038 )

• occasionally displayed

embryo

embryonic growth arrest ( J:33038 )

• arrested at E11.5

muscle

trabecula carnea hypoplasia ( J:33038 )

• severly impaired formation; lack of intertrabecular sinusiods was noted

decreased cardiac muscle contractility ( J:33038 )

• depressed contractility was observed

nervous system

abnormal cranial ganglia morphology ( J:33038 )

• the proximal part of the facio-acoustic ganglion complex is abnormal; mean area reduced by 30%

• the petrosal and nodose ganglia appear normal

• affected ganglia appear to have cells that originated in the crainal neural crest and unaffected ganglia appear to have cells that originated in the placode

abnormal trigeminal ganglion morphology ( J:33038 )

• the proximal region including the mandibular branch and CNS projection is missing

• total area of the ganglion is reduced by 66%

• disruption of cellular organization, vacuolization and karyorrhexis was seen

abnormal glossopharyngeal nerve morphology ( J:33038 )

• compromised projections to the brain stem

abnormal mandibular nerve branching ( J:33038 )

abnormal vagus nerve morphology ( J:33038 )

• compromised projections to the brain stem