Analysis Tools
mortality/aging
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• all mutant embryos die by E11.5
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cardiovascular system
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• however, atria were morphologically normal
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• at E10.5, the endocardial cusion was not closed, and the mesenchymal cells forming the cusion were reduced in number
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• frequently observed
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• frequently observed
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muscle
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• however, atria were morphologically normal
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nervous system
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• no identifiable immature oligodendrocytes were observed in spinal cord explant cultures
• addition of recombinant Nrg1 protein to the cultures rescued this phenotype
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• generation of radial glia is impaired
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• Schwann cell precursors in the trunk appear reduced in number
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• cranial ganglia cells are reduced in number
• distinct ganglia are altered to different extents
• geniculate and vestibular-cochlea ganglia appear unaffected
• loss of neural-crest derived cells in the ganglia are thought to account for the morphological changes
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• projections are disorganized; projections to CNS often absent
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• projections are disorganized
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• the jugular ganglion is described as abnormal
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• cranial nerves are severely altered, whereas other peripheral projections appear normal
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• mandibular projections and axonal connections between trigeminus and hindbrain are lost
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• lost, particularly the dorsal part
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cellular
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• no identifiable immature oligodendrocytes were observed in spinal cord explant cultures
• addition of recombinant Nrg1 protein to the cultures rescued this phenotype
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• generation of radial glia is impaired
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• Schwann cell precursors in the trunk appear reduced in number
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growth/size/body
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• frequently observed
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