Phenotypes Associated with This Genotype

Genotype
MGI:2175158

• Allelic Composition: Notch1^tm1Grid/Notch1^tm1Grid
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:17509 )

• many resorbed embryos by E10.5, surviving embryos are severely retarded but with beating hearts in distended pericardial sacs

• all homozygous embryos are resorbed at E11.5

cardiovascular system

abnormal dorsal aorta morphology ( J:62571 )

• collapsed appearance of dorsal aortae

abnormal placenta vasculature ( J:62571 )

• embryonic blood vessels fail to invade trophoblast

decreased angiogenesis ( J:62571 )

• vasculogenesis was normal but subsequent remodeling failed

absent vitelline blood vessels ( J:62571 )

• pale yolk sacs lacking obvious blood vessels

embryo

abnormal placenta vasculature ( J:62571 )

• embryonic blood vessels fail to invade trophoblast

absent vitelline blood vessels ( J:62571 )

• pale yolk sacs lacking obvious blood vessels

embryonic growth retardation ( J:17509 )

• normal at E8.5 but retarded at E9.5 (14-16 somites rather than 20-25)

pale yolk sac ( J:62571 )

• pale yolk sacs lacking obvious blood vessels

growth/size/body

embryonic growth retardation ( J:17509 )

• normal at E8.5 but retarded at E9.5 (14-16 somites rather than 20-25)