Mouse Genome Informatics
ht
    Nf1tm1Tyj/Nf1+
involves: 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• 75% of mice develop tumors over 27 months, including lymphomas, leukemias, lung adenocarcinomas, hepatomas, fibrosarcomas, neurofibrosarcoma, and adrenal tumors
• mice develop similar types of tumors seen in patients with neurofibromatosis, but do not present any other classical features of the disease
• some heterozygotes developed lymphoid leukemia and myeloid leukemia

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Neurofibromatosis, Type I; NF1 162200 J:18542