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Phenotypes Associated with This Genotype
Genotype
MGI:2175144
Allelic
Composition
Nf1tm1Tyj/Nf1+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system

nervous system

endocrine/exocrine glands

respiratory system

neoplasm
• 75% of mice develop tumors over 27 months, including lymphomas, leukemias, lung adenocarcinomas, hepatomas, fibrosarcomas, neurofibrosarcoma, and adrenal tumors
• mice develop similar types of tumors seen in patients with neurofibromatosis, but do not present any other classical features of the disease
• some heterozygotes developed lymphoid leukemia and myeloid leukemia

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Neurofibromatosis, Type I; NF1 162200 J:18542


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory