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Phenotypes Associated with This Genotype
Genotype
MGI:2175110
Allelic
Composition
MipCat-Fr/MipCat-Fr
Genetic
Background
involves: A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCat-Fr mutation (1 available); any Mip mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 14 days of gestation, the centrally located nuclei of the lens fibers are seen to be abnormally small and dark with indistinct nucleoli (J:5104)
• nuclear degeneration is followed by swelling and vacuolization of the lens fibers (J:5104)
• the main lens fiber mass degenerates (J:5114)
• the epithelial cells form multiple layers of atypical cells (J:5114)
• by electron microscopy, changes can be seen in the nuclear envelope of the primary lens fibers in 12-day embryos (J:30791)
• lens opacities are visible when the eyes first open at 14 days

Mouse Models of Human Disease
OMIM ID Ref(s)
Cataract 15, Multiple Types; CTRCT15 615274 J:31574


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory