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Phenotypes Associated with This Genotype
Genotype
MGI:2175082
Allelic
Composition
Itgb6tm1Des/Itgb6tm1Des
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Juvenile baldness in Itgb6tm1Des/Itgb6tm1Des mice

respiratory system
• mice exhibit increased airway responsiveness to acetylcholine (J:33139)
• mice exhibit increased airway responsiveness to acetylcholine (J:33139)
• mononuclear cells consisting of a mixed lymphocyte infiltrate are present in the lung epithelium (J:33139)
• however, mice do not display any overt signs of lung infection (J:33139)
• mononuclear cells consisting of a mixed lymphocyte infiltrate are present in the lung epithelium (J:33139)
• however, mice do not display any overt signs of lung infection (J:33139)

immune system
• mice exhibit increased airway responsiveness to acetylcholine (J:33139)
• mice exhibit increased airway responsiveness to acetylcholine (J:33139)

integument
• mice fail to develop hair on the tops of their heads, the backs of their necks and the inner surface of their thighs (J:33139)
• however, by 20 to 30 days hair growth on the head and neck resumes (J:33139)
• mice fail to develop hair on the tops of their heads, the backs of their necks and the inner surface of their thighs (J:33139)
• however, by 20 to 30 days hair growth on the head and neck resumes (J:33139)
• degenerating follicle cells are surrounded by mononuclear cells consisting of a macrophage infiltrate (J:33139)
• degenerating follicle cells are surrounded by mononuclear cells consisting of a macrophage infiltrate (J:33139)
• mixed cellular infiltration of dermis, macrophages; mixed cellular infiltration of airway walls, mixed lymphocytes (J:33139)
• mixed cellular infiltration of dermis, macrophages; mixed cellular infiltration of airway walls, mixed lymphocytes (J:33139)

Mouse Models of Human Disease
OMIM ID Ref(s)
Asthma, Susceptibility to 600807 J:33139


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory