Phenotypes Associated with This Genotype

Genotype
MGI:2175079

• Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• born alive but die within minutes after birth

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 45% of wild-type

muscle

muscle hypoplasia ( J:15108 )

• reduction in number of myocytes in the three layers of the anterolateral abdominal muscle and in neck, limb, and respiratory muscles

respiratory system

atelectasis ( J:15108 )

• lung tissue fails to float on water, indicating that air never reached the alveoli

respiratory failure ( J:15108 )

• failure at birth

skeleton

delayed bone ossification ( J:15108 )

• ossification centers of cranial and facial bones appear later, after about a lag of 2 days, except for the interparietal bone, which exhibits an even longer delay of about 4 days

• developmental delay in the bones of the trunk and extremities is 1-2 days

nervous system

decreased oligodendrocyte progenitor number ( J:15108 )

• fewer oligodendrocyte progenitors develop in cultured E18.5 forebrain cells

abnormal brainstem morphology ( J:15108 )

• increase in cell density in the brainstem

abnormal spinal cord morphology ( J:15108 )

• cellular density in the mantle zone is higher at E14.5-E18.5

homeostasis/metabolism

cyanosis ( J:15108 )

• mutants are born alive but become cyanotic and die within minutes

integument

abnormal hair follicle morphology ( J:15108 )

• hair follicles are more widely spaced than in wild-type

decreased hair follicle number ( J:15108 )

• decrease in the absolute number of hair follicles

small hair follicles ( J:15108 )

thin epidermis stratum spinosum ( J:15108 )

thin epidermis ( J:15108 )

• the strata of the epidermis (basale, spinosum, granulosum, and corneum) is extremely thin

translucent skin ( J:15108 )

cellular

decreased oligodendrocyte progenitor number ( J:15108 )

• fewer oligodendrocyte progenitors develop in cultured E18.5 forebrain cells