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Phenotypes Associated with This Genotype
Genotype
MGI:2175075
Allelic
Composition
Irf8tm1Hor/Irf8+
Genetic
Background
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8tm1Hor mutation (1 available); any Irf8 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 9% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis

neoplasm
• hematological neoplasia
• 9% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis

hematopoietic system
• deranged hematopoiesis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial chronic myelocytic leukemia-like syndrome DOID:0060761 OMIM:600080
J:36038


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory