Phenotypes Associated with This Genotype

Genotype
MGI:2175021

• Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss
• Genetic Background: either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:50768 )

growth/size/body

decreased fetal size ( J:50768 )

• crown-rump lengths of E17.5 fetuses are on average 12% shorter than controls

respiratory system

abnormal lung development ( J:50768 )

impaired branching involved in bronchus morphogenesis ( J:50768 )

• initial branching of the primordial bronchi is absent

impaired branching involved in preterminal bronchiole morphogenesis ( J:50768 )

• pulmonary bronchiolar development does not occur

abnormal branching involved in trachea morphogenesis ( J:50768 )

• initial tracheal development is normal, however the trachea terminates at the level of the thymus and no main-stem bronchi or subsequent pulmonary bronchiolar and alveolar development occurs

impaired lung alveolus development ( J:50768 )

• alveolar development does not occur

absent lungs ( J:50768 )

limbs/digits/tail

absent limb buds ( J:50768 )

• complete absence of budding limbs at E9.5 and E10.5

decreased limb number ( J:50768 )

absent forelimb ( J:50768 )

absent hindlimb ( J:50768 )

skeleton

abnormal pelvic girdle bone morphology ( J:50768 )

• exhibit only a rudimentary cartilaginous pelvic girdle at E18.5

embryo

absent limb buds ( J:50768 )

• complete absence of budding limbs at E9.5 and E10.5