Phenotypes Associated with This Genotype

Genotype
MGI:2175000

• Allelic Composition: Psen2^tm1Bdes/Psen2^tm1Bdes
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Phenotypical analysis of Psen2^tm1Bdes/Psen2^tm1Bdes mice

respiratory system

abnormal pulmonary alveolus wall morphology ( J:58118 )

• from 3 months of age, show a thickening of alveolar walls, with broad strands of fibrotic tissues

pulmonary fibrosis ( J:58118 )

• develop mild pulmonary fibrosis with age

abnormal respiratory system physiology ( J:58118 )

• apoptosis is evident in the lung parenchyma, within the vascular endothelium and bronchial epithelium

lung hemorrhage ( J:58118 )

• at 3 and 6 months of age, observe hemorrhages within large groups of alveoli and their adjoining airways

increased lung endothelial cell apoptosis ( J:58118 )

• apoptosis is evident within the vascular endothelium

cardiovascular system

lung hemorrhage ( J:58118 )

• at 3 and 6 months of age, observe hemorrhages within large groups of alveoli and their adjoining airways

limbs/digits/tail

limbs/digits/tail phenotype ( J:58118 )

N • surprisingly, no alterations in digit formation are seen

nervous system

nervous system phenotype ( J:58118 )

N • surprisingly, no alterations in brain anatomy are seen

cellular

increased lung endothelial cell apoptosis ( J:58118 )

• apoptosis is evident within the vascular endothelium