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Phenotypes Associated with This Genotype
Genotype
MGI:2174933
Allelic
Composition
Aqp3tm1Ask/Aqp3tm1Ask
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp3tm1Ask mutation (0 available); any Aqp3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice
• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice
• the osmotic water permeability of the basolateral membrane of cortical collecting ducts is decreased at least 3-fold compared to wild-type mice
• expression of Aqp2 is decreased particularly in the renal cortex; however expression of Aqp1 and Aqp4 is similar to wild-type
• about a 10-fold increase in urine output; however, kidney and urinary bladder morphology are similar to wild-type

behavior/neurological
• about a 10-fold increase in fluid consumption

homeostasis/metabolism
• plasma osmolality is mildly elevated but serum electrolyte, urea, creatinine, and phosphorus levels are similar to wild-type
• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice
• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
nephrogenic diabetes insipidus DOID:12387 OMIM:125800
OMIM:304800
J:61675


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/23/2017
MGI 6.09
The Jackson Laboratory