Mouse Genome Informatics
hm
    Aqp3tm1Ask/Aqp3tm1Ask
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
renal/urinary system
• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice
• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice
• the osmotic water permeability of the basolateral membrane of cortical collecting ducts is decreased at least 3-fold compared to wild-type mice
• expression of Aqp2 is decreased particularly in the renal cortex; however expression of Aqp1 and Aqp4 is similar to wild-type
• about a 10-fold increase in urine output; however, kidney and urinary bladder morphology are similar to wild-type

behavior/neurological
• about a 10-fold increase in fluid consumption

homeostasis/metabolism
• plasma osmolality is mildly elevated but serum electrolyte, urea, creatinine, and phosphorus levels are similar to wild-type
• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice
• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Insipidus, Nephrogenic, Autosomal 125800 J:61675