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Phenotypes Associated with This Genotype
Genotype
MGI:2174933
Allelic
Composition
Aqp3tm1Ask/Aqp3tm1Ask
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp3tm1Ask mutation (0 available); any Aqp3 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice (J:61675)
• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice (J:61675)
• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice (J:61675)
• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice (J:61675)
• the osmotic water permeability of the basolateral membrane of cortical collecting ducts is decreased at least 3-fold compared to wild-type mice (J:61675)
• expression of Aqp2 is decreased particularly in the renal cortex; however expression of Aqp1 and Aqp4 is similar to wild-type (J:61675)
• the osmotic water permeability of the basolateral membrane of cortical collecting ducts is decreased at least 3-fold compared to wild-type mice (J:61675)
• expression of Aqp2 is decreased particularly in the renal cortex; however expression of Aqp1 and Aqp4 is similar to wild-type (J:61675)
• about a 10-fold increase in urine output; however, kidney and urinary bladder morphology are similar to wild-type (J:61675)
• about a 10-fold increase in urine output; however, kidney and urinary bladder morphology are similar to wild-type (J:61675)

behavior/neurological
• about a 10-fold increase in fluid consumption (J:61675)
• about a 10-fold increase in fluid consumption (J:61675)

homeostasis/metabolism
• plasma osmolality is mildly elevated but serum electrolyte, urea, creatinine, and phosphorus levels are similar to wild-type (J:61675)
• plasma osmolality is mildly elevated but serum electrolyte, urea, creatinine, and phosphorus levels are similar to wild-type (J:61675)
• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice (J:61675)
• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice (J:61675)
• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice (J:61675)
• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice (J:61675)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Insipidus, Nephrogenic, Autosomal 125800 J:61675


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory