Analysis Tools
homeostasis/metabolism
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• heterozygotes subjected to renal ischemia-reperfusion (IR) under sevoflurane anesthesia display significantly higher plasma creatinine levels than wild-type mice subjected to renal IR under either sevoflurane or pentobarbital sodium anesthesia
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• sevoflurane fails to protect heterozygotes against IR-induced renal tubular necrosis, unlike in wild-type controls
• sevoflurane also fails to protect primary cultures of renal proximal tubules against H2O2-induced necrosis, unlike in wild-type controls
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• heterozygotes are not protected against renal IR injury under anesthesia with sevoflurane (a volatile anesthetic), unlike similarly treated wild-type controls
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renal/urinary system
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• heterozygotes subjected to renal IR injury under sevoflurane anesthesia exhibit more severe renal tubular necrosis than similarly treated wild-type controls
• in culture, sevoflurane-treated proximal tubule cells isolated from heterozygous mice are not protected against H2O2-induced necrosis, unlike similarly treated wild-type proximal tubule cells
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• heterozygotes are not protected against renal IR injury under anesthesia with sevoflurane (a volatile anesthetic), unlike similarly treated wild-type controls
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cellular
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• heterozygotes subjected to renal IR injury under sevoflurane anesthesia exhibit more severe renal tubular necrosis than similarly treated wild-type controls
• in culture, sevoflurane-treated proximal tubule cells isolated from heterozygous mice are not protected against H2O2-induced necrosis, unlike similarly treated wild-type proximal tubule cells
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