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Phenotypes Associated with This Genotype
Genotype
MGI:2174925
Allelic
Composition
Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic
Background
involves: 129S2/SvPas * CF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb1tm1Doe mutation (4 available); any Tgfb1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around 3 weeks of age from wasting (J:2892)
• mice die around 3 weeks of age from wasting (J:2892)

growth/size/body
• at ~3 weeks of age, mice exhibit severe wasting (J:2892)
• at ~3 weeks of age, mice exhibit severe wasting (J:2892)

hematopoietic system
• average number of white blood cells is usually elevated in mutants (J:2892)
• average number of white blood cells is usually elevated in mutants (J:2892)
• in most animals, spleens are smaller than in controls (J:2892)
• in most animals, spleens are smaller than in controls (J:2892)

immune system
• average number of white blood cells is usually elevated in mutants (J:2892)
• average number of white blood cells is usually elevated in mutants (J:2892)
• in most animals, spleens are smaller than in controls (J:2892)
• in most animals, spleens are smaller than in controls (J:2892)
• Peyer's patches possess less distinct germinal centers compared to normal controls (J:2892)
• Peyer's patches possess less distinct germinal centers compared to normal controls (J:2892)
• Peyer's patches are fewer than normal (J:2892)
• Peyer's patches are fewer than normal (J:2892)
• >60% of mice have slightly enlarged lymph nodes (J:2892)
• >60% of mice have slightly enlarged lymph nodes (J:2892)
• mild to moderate inflammation of serosa of internal organs (stomach, intestine, kidney, ovary, and testis) is seen in some mice (J:2892)
• mild to moderate inflammation of serosa of internal organs (stomach, intestine, kidney, ovary, and testis) is seen in some mice (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation; in some animals, inflammation involves pericardium, myocardium and endocardium of atria and ventricles (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation; in some animals, inflammation involves pericardium, myocardium and endocardium of atria and ventricles (J:2892)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammatory cell infiltration is seen in ~50% of animals (J:2892)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammatory cell infiltration is seen in ~50% of animals (J:2892)
• inflammation is mainly granulocytic (60% neutrophils) (J:2892)
• inflammation is mainly granulocytic (60% neutrophils) (J:2892)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammation is seen in ~50% of animals (J:2892)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammation is seen in ~50% of animals (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation (J:2892)
• some mice show conjunctivitis, while others display inflammation of striated ocular muscle, or lacrimal gland inflammation (J:2892)
• some mice show conjunctivitis, while others display inflammation of striated ocular muscle, or lacrimal gland inflammation (J:2892)
• seen in some animals prior to death (J:2892)
• seen in some animals prior to death (J:2892)
• inflammatory cell infiltration is primarily periductal; granulocytes and lymphocytes are ~equal in number (J:2892)
• inflammatory cell infiltration is primarily periductal; granulocytes and lymphocytes are ~equal in number (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation; various muscles (diaphragm, masseter, leg) (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation; various muscles (diaphragm, masseter, leg) (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation (J:2892)
• seen in some animals prior to death (J:2892)
• seen in some animals prior to death (J:2892)

liver/biliary system
• inflammatory cell infiltration is primarily periductal; granulocytes and lymphocytes are ~equal in number (J:2892)
• inflammatory cell infiltration is primarily periductal; granulocytes and lymphocytes are ~equal in number (J:2892)
• seen in some animals (J:2892)
• seen in some animals (J:2892)

cardiovascular system
• variable degrees are observed (J:2892)
• variable degrees are observed (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation; in some animals, inflammation involves pericardium, myocardium and endocardium of atria and ventricles (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation; in some animals, inflammation involves pericardium, myocardium and endocardium of atria and ventricles (J:2892)

muscle
• primarily (~80%) lymphocytic and plasmacytic inflammation; various muscles (diaphragm, masseter, leg) (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation; various muscles (diaphragm, masseter, leg) (J:2892)
• diaphragms show inflammation and necrosis severe enough to interfere with respiration (J:2892)
• diaphragms show inflammation and necrosis severe enough to interfere with respiration (J:2892)

endocrine/exocrine glands
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammatory cell infiltration is seen in ~50% of animals (J:2892)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammatory cell infiltration is seen in ~50% of animals (J:2892)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammation is seen in ~50% of animals (J:2892)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammation is seen in ~50% of animals (J:2892)

digestive/alimentary system
• severe focal ulceration and/or hyperplasia of basal epithelial layer accompanies inflammation; non-glandular portion of stomach in most mice shows some degree of acanthosis and inflammatory cell infiltration (J:2892)
• severe focal ulceration and/or hyperplasia of basal epithelial layer accompanies inflammation; non-glandular portion of stomach in most mice shows some degree of acanthosis and inflammatory cell infiltration (J:2892)
• variable degrees are observed (J:2892)
• variable degrees are observed (J:2892)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammatory cell infiltration is seen in ~50% of animals (J:2892)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammatory cell infiltration is seen in ~50% of animals (J:2892)
• inflammation is mainly granulocytic (60% neutrophils) (J:2892)
• inflammation is mainly granulocytic (60% neutrophils) (J:2892)

respiratory system
• primarily (~80%) lymphocytic and plasmacytic inflammation (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation (J:2892)

vision/eye
• some mice show conjunctivitis, while others display inflammation of striated ocular muscle, or lacrimal gland inflammation (J:2892)
• some mice show conjunctivitis, while others display inflammation of striated ocular muscle, or lacrimal gland inflammation (J:2892)
• seen in some animals prior to death (J:2892)
• seen in some animals prior to death (J:2892)

behavior/neurological
• seen in some animals prior to death (J:2892)
• seen in some animals prior to death (J:2892)

nervous system
• primarily (~80%) lymphocytic and plasmacytic inflammation (J:2892)
• primarily (~80%) lymphocytic and plasmacytic inflammation (J:2892)

homeostasis/metabolism
N
• cytokine levels are comparable to controls (J:2892)
• cytokine levels are comparable to controls (J:2892)

integument
• seen in some animals prior to death (J:2892)
• seen in some animals prior to death (J:2892)
• seen in some animals prior to death (J:2892)
• seen in some animals prior to death (J:2892)

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:2892


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory