Mouse Genome Informatics
hm
    Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * CF1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice die around 3 weeks of age from wasting

growth/size
• at ~3 weeks of age, mice exhibit severe wasting

hematopoietic system
• average number of white blood cells is usually elevated in mutants
• in most animals, spleens are smaller than in controls

immune system
• average number of white blood cells is usually elevated in mutants
• in most animals, spleens are smaller than in controls
• Peyer's patches are fewer and possess less distinct germinal centers compared to normal controls
• >60% of mice have slightly enlarged lymph nodes
• mild to moderate inflammation of serosa of internal organs (stomach, intestine, kidney, ovary, and testis) is seen in some mice
• primarily (~80%) lymphocytic and plasmacytic inflammation; in some animals, inflammation involves pericardium, myocardium and endocardium of atria and ventricles
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammatory cell infiltration is seen in ~50% of animals
• inflammation is mainly granulocytic (60% neutrophils)
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammation is seen in ~50% of animals
• primarily (~80%) lymphocytic and plasmacytic inflammation
• some mice show conjunctivitis, while others display inflammation of striated ocular muscle, or lacrimal gland inflammation
• seen in some animals prior to death
• inflammatory cell infiltration is primarily periductal; granulocytes and lymphocytes are ~equal in number
• primarily (~80%) lymphocytic and plasmacytic inflammation; various muscles (diaphragm, masseter, leg)
• primarily (~80%) lymphocytic and plasmacytic inflammation
• seen in some animals prior to death

liver/biliary system
• inflammatory cell infiltration is primarily periductal; granulocytes and lymphocytes are ~equal in number
• seen in some animals

cardiovascular system
• variable degrees are observed
• primarily (~80%) lymphocytic and plasmacytic inflammation; in some animals, inflammation involves pericardium, myocardium and endocardium of atria and ventricles

muscle
• primarily (~80%) lymphocytic and plasmacytic inflammation; various muscles (diaphragm, masseter, leg)
• diaphragms show inflammation and necrosis severe enough to interfere with respiration

endocrine/exocrine glands
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammatory cell infiltration is seen in ~50% of animals
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammation is seen in ~50% of animals

digestive/alimentary system
• severe focal ulceration and/or hyperplasia of basal epithelial layer accompanies inflammation; non-glandular portion of stomach in most mice shows some degree of acanthosis and inflammatory cell infiltration
• variable degrees are observed
• inflammatory cell infiltration is primarily periductal; primarily (~80%) lymphocytic and plasmacytic inflammation; some degree of multifocal inflammatory cell infiltration is seen in ~50% of animals
• inflammation is mainly granulocytic (60% neutrophils)

respiratory system
• primarily (~80%) lymphocytic and plasmacytic inflammation

vision/eye
• some mice show conjunctivitis, while others display inflammation of striated ocular muscle, or lacrimal gland inflammation
• seen in some animals prior to death

behavior/neurological
• seen in some animals prior to death

nervous system
• primarily (~80%) lymphocytic and plasmacytic inflammation

homeostasis/metabolism
N
• cytokine levels are comparable to controls (J:2892)

integument
• seen in some animals prior to death
• seen in some animals prior to death

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:2892