Phenotypes Associated with This Genotype

Genotype
MGI:2174795

• Allelic Composition: Uchl3^tm1Tilg/Uchl3^tm1Tilg
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina layer morphology ( J:83810 )

• the distal photoreceptor region is dramatically shortened

abnormal retina outer nuclear layer morphology ( J:83810 )

• mice show an indistinguishable retinal phenotype to Lmo7^tm1Tilg with dramatically reduced cell numbers in this layer

muscle

abnormal skeletal muscle fiber morphology ( J:83810 )

• mice show similar defects to Lmo7^tm1Tilg mice with increased nuclei number and inclusions, but with a lower penetrance and later onset; nuclear defects are observed in 5/9 homozygotes at 170 days after birth compared to 6/6 Lmo7-null mice at 80 days of age

growth/size/body

decreased body weight ( J:71819 )

• weight is 20% less than wild-type by 80 days of age

nervous system

abnormal dorsal root ganglion morphology ( J:71819 )

• 3.6-fold increase in small basophilic DRG cell bodies

axonal dystrophy ( J:71819 )

immune system

immune system phenotype ( J:61093 )

N • initial investigation of thymi show no significant differences from wild-type

reproductive system

reproductive system phenotype ( J:61093 )

N • initial investigation of testes show no significant differences from wild-type