Phenotypes Associated with This Genotype

Genotype
MGI:2174781

• Allelic Composition: Trp53^tm1Sia/Trp53^tm1Sia
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:36762 )

• tumors develop in all mice at 3 to 6 months of age

increased T cell derived lymphoma incidence ( J:36762 )

• most tumors (>90%) are T cell lymphomas

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:85569 )

• MEFs are more resistant to UV-induced apoptosis than wild-type MEFs

increased sensitivity to induced cell death ( J:85569 )

• MEFs are more sensitive to etoposide, adriamycin, or cisplatin induced apoptosis than wild-type MEFs

abnormal cell proliferation ( J:36762 )

• several cell types, including lens epithelial cells, show enhanced proliferation (doubling potential) in culture compared to wild-type cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:36762 )

• most tumors (>90%) are T cell lymphomas