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Phenotypes Associated with This Genotype
Genotype
MGI:2174781
Allelic
Composition
Trp53tm1Sia/Trp53tm1Sia
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Sia mutation (11 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• most tumors (>90%) are T cell lymphomas

neoplasm
• tumors develop in all mice at 3 to 6 months of age
• most tumors (>90%) are T cell lymphomas

cellular
• MEFs are more resistant to UV-induced apoptosis than wild-type MEFs
• MEFs are more sensitive to etoposide, adriamycin, or cisplatin induced apoptosis than wild-type MEFs
• several cell types, including lens epithelial cells, show enhanced proliferation (doubling potential) in culture compared to wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory