Analysis Tools
mortality/aging
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• homozygotes are born alive but die within 5-10 min after birth
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homeostasis/metabolism
respiratory system
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• mutant lung epithelia fail to undergo branching morphogenesis
|
|
• mutant lungs are severely hypoplastic
|
|
• homozygotes show absence of respiratory alveoli
|
|
• newborn homozygotes have difficulty in breathing and display gasping motions
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hematopoietic system
|
• splenic precursors are specified, as shown by normal expression of early markers of spleen development in the splenic anlage at E12.5; however, the mutant splenic anlage fails to expand and, in its absence, the splenic primordium undergoes apoptotic cell death
|
absent spleen
(
J:64068
)
|
• newborn homozygotes display complete absence of a spleen
• in contrast, the stomach and pancreas are properly located
|
renal/urinary system
|
• homozygotes display atrophic kidney glomeruli
|
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• mutant kidneys are severely hypoplastic
|
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• mutant kidney epithelia fail to undergo branching morphogenesis
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immune system
|
• splenic precursors are specified, as shown by normal expression of early markers of spleen development in the splenic anlage at E12.5; however, the mutant splenic anlage fails to expand and, in its absence, the splenic primordium undergoes apoptotic cell death
|
absent spleen
(
J:64068
)
|
• newborn homozygotes display complete absence of a spleen
• in contrast, the stomach and pancreas are properly located
|
integument
