Analysis Tools
mortality/aging
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• homozygotes die by E10.5; only resorption sites with small embryonic remnants are detected at E11.5
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embryo
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• at E8.75-E9.0, mutant yolk sacs show absence of major vitelline vessels
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• ~1/3 of homozygotes fail to complete axial rotation
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• only a few mutant embryos develop beyond 18 somites (range 8-20)
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• homozygotes become increasingly retarded after E8.75
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• at E8.75-E9.0, mutant yolk sacs show absence of blood islands
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pale yolk sac
(
J:27458
)
|
• by E8.75-E9.0, mutant yolk sacs are significantly pale
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• homozygotes exhibit failure of yolk sac hematopoiesis, with no erythrocytes found in embryonic vessels
• in vitro, cultures of E8.5-E9.5 mutant yolk sacs display absence of all hematopoietic colony types
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cardiovascular system
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• at E8.75-E9.0, mutant yolk sacs show absence of major vitelline vessels
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• at E8.75-E9.0, mutant embryos exhibit dilated pericardial sacs but normal cardiac contraction
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homeostasis/metabolism
skin edema
(
J:27458
)
|
• by E8.75-E9.0, mutant embryos are edematous
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growth/size/body
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• homozygotes become increasingly retarded after E8.75
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hematopoietic system
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• homozygotes exhibit failure of yolk sac hematopoiesis, with no erythrocytes found in embryonic vessels
• in vitro, cultures of E8.5-E9.5 mutant yolk sacs display absence of all hematopoietic colony types
|
integument
skin edema
(
J:27458
)
|
• by E8.75-E9.0, mutant embryos are edematous
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