Phenotypes Associated with This Genotype

Genotype
MGI:2174750

• Allelic Composition: sy/sy
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:208 )

• within 1 month of birth

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:208 )

head bobbing ( J:208 )

circling ( J:208 )

hearing/vestibular/ear

abnormal ear morphology ( J:13002 )

abnormal semicircular canal morphology ( J:13002 )

• thin semicircular canals

abnormal membranous labyrinth morphology ( J:13002 )

• development of excessive mesenchymal tissue followed by collapse of endolymphatic space and degeneration of membraneous labyrinth

abnormal otic capsule morphology ( J:13002 )

abnormal hearing physiology ( J:13002 )

deafness ( J:208 )

limbs/digits/tail

abnormal digit morphology ( J:208 )

syndactyly ( J:208 )

• variable penetrance

• usually of digits 2 and 3 or 3 and 4

skeleton

decreased diameter of long bones ( J:12945 )

• thin long bones

abnormal scapula morphology ( J:12945 )

abnormal axial skeleton morphology ( J:12945 )

abnormal sacral vertebrae morphology ( J:12945 )

decreased bone mineral density ( J:12945 )

abnormal skeleton development ( J:12945 )

synostosis ( J:12945 )

• synostosis of phalanges

• variable penetrance