Phenotypes Associated with This Genotype

Genotype
MGI:2170803

• Allelic Composition: Ift88^tm1Rpw/Ift88^tm1Rpw
• Genetic Background: FVB.129-Ift88^tm1Rpw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:62025 )

• die between E10.5 and E11.5

embryo

absent embryonic cilia ( J:62025 )

• absent from the surface of ventral node cells

abnormal pharyngeal arch morphology ( J:62025 )

• poorly differentiated at E9.5

abnormal left-right axis patterning ( J:62025 )

• bilateral expression of Lefty2 and Nodal at E8.0

embryonic growth retardation ( J:62025 )

• slightly runted at E9.5

broad limb buds ( J:62025 )

kinked neural tube ( J:62025 )

• at E9.5

wavy neural tube ( J:62025 )

• undulations present at E9.5

cardiovascular system

abnormal direction of heart looping ( J:62025 )

• randomization of the direction of looping

distended pericardium ( J:62025 )

• at E9.5 and E10.5

limbs/digits/tail

broad limb buds ( J:62025 )

nervous system

kinked neural tube ( J:62025 )

• at E9.5

wavy neural tube ( J:62025 )

• undulations present at E9.5

abnormal forebrain development ( J:62025 )

• poorly differentiated at E9.5

abnormal hindbrain development ( J:62025 )

• poorly differentiated at E9.5

abnormal midbrain development ( J:62025 )

• poorly differentiated at E9.5

growth/size/body

embryonic growth retardation ( J:62025 )

• slightly runted at E9.5

craniofacial

abnormal pharyngeal arch morphology ( J:62025 )

• poorly differentiated at E9.5

cellular

absent embryonic cilia ( J:62025 )

• absent from the surface of ventral node cells