Phenotypes Associated with This Genotype

Genotype
MGI:2170429

• Allelic Composition: Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:15678 )

• survival normal through to birth

• many die within the first 5 days of life

• surviving mice are fertile

skeleton

asymmetric sternocostal joints ( J:15678 )

• the rib fusions on the two sides of the stermum are offset from one another

abnormal cervical vertebrae morphology ( J:15678 )

abnormal cervical atlas morphology ( J:15678 )

• the atlas is narrower than normal

• intermediate transformation of atlas in 15% of mice, remains independent vertebrum but osseous bridges develop to skull

• atlantal neural arch is usually incomplete

fusion of atlas and occipital bones ( J:15678 )

• the anterior arch of the atlas is assimilated into caudal part of the basioccipital bone

abnormal cervical axis morphology ( J:15678 )

• axis lacks superior articular surfaces

• thicker neural arch on axis

• cartilaginous foramina of normal atlas now in axis (sometimes only unilateral)

absent odontoid process ( J:15678 )

• axis lacks dens

cardiovascular system

abnormal vertebral artery morphology ( J:15678 )

• vertebral artery enters spinal canal more caudally than normal

nervous system

abnormal spinal nerve morphology ( J:15678 )

• first cervical nerve runs through a foramen in the floor of the skull

craniofacial

fusion of atlas and occipital bones ( J:15678 )

• the anterior arch of the atlas is assimilated into caudal part of the basioccipital bone