Phenotypes associated with this allele

• Allele Symbol: Tardbp^tm1.1Neas
• Allele Name: targeted mutation 1.1, Neil A Shneider
• Allele ID: MGI:6405194
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tardbp^tm1.1Neas/Tardbp^tm1.1Neas	B6(C3)-Tardbp^tm1.1Neas	MGI:6405398
ht2	Tardbp^tm1.1Neas/Tardbp^+	B6(C3)-Tardbp^tm1.1Neas	MGI:6405399

Genotype
MGI:6405398

hm1

• Allelic Composition: Tardbp^tm1.1Neas/Tardbp^tm1.1Neas
• Genetic Background: B6(C3)-Tardbp^tm1.1Neas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:283769 )

N • no motor neuron loss is seen in the L4-5 spinal cord at 1, 1.5 or 2 years of age and no TDP-43 aggregation in ChAT+ neurons is seen in the lumbar spinal cord

microgliosis ( J:283769 )

• 2 year old mice show microgliosis in the lumbar spinal cord

astrocytosis ( J:283769 )

• 2 year old mice show astrocytosis in the lumbar spinal cord

abnormal motor neuron innervation pattern ( J:283769 )

• denervation of the tibialis anterior muscle is seen at around 2.5 years of age but not 2 years, with asymmetric innervation of the tibialis anterior muscle and mice with the most denervation also showing the highest degree of asymmetry

immune system

microgliosis ( J:283769 )

• 2 year old mice show microgliosis in the lumbar spinal cord

hematopoietic system

microgliosis ( J:283769 )

• 2 year old mice show microgliosis in the lumbar spinal cord

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 10		DOID:0060201	OMIM:612069	J:283769

Genotype
MGI:6405399

ht2

• Allelic Composition: Tardbp^tm1.1Neas/Tardbp⁺
• Genetic Background: B6(C3)-Tardbp^tm1.1Neas

nervous system

nervous system phenotype ( J:283769 )

N • mice show normal number of motor neurons in the lumbar levels, no motor neuron degeneration at 2 years of age, no denervation of the tibialis anterior muscle endplate and, no TDP-43-positive neuronal cytoplasmic inclusions