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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Btbd9tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6384248
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Btbd9tm1c(EUCOMM)Wtsi/Btbd9tm1c(EUCOMM)Wtsi
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N MGI:6488227
cn2
Btbd9tm1c(EUCOMM)Wtsi/Btbd9tm1c(EUCOMM)Wtsi
Emx1tm1(cre)Yql/Emx1+
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N MGI:6488233


Genotype
MGI:6488227
cn1
Allelic
Composition
Btbd9tm1c(EUCOMM)Wtsi/Btbd9tm1c(EUCOMM)Wtsi
Tg(Pcp2-cre)2Mpin/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btbd9tm1c(EUCOMM)Wtsi mutation (0 available); any Btbd9 mutation (40 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit an increase in voluntary activity level in the wheel-running test during the light phase, but no change during the dark phase; activity is especially high at 9 am and especially low during the 1st half of the active phase
• mice exhibit an increase in activity level during the rest (light) phase and during the active (dark) phase in the continuous open field
• however, mice show no difference in the latency to withdraw from the heat stimuli in the tail-flick test
• analysis of sleep-like behaviors indicates an increase in probability of waking in the rest phase, especially at 7 am, 8 am and the 2nd half of the rest phase, but not in the active phase

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
restless legs syndrome DOID:0050425 OMIM:PS102300
J:298663




Genotype
MGI:6488233
cn2
Allelic
Composition
Btbd9tm1c(EUCOMM)Wtsi/Btbd9tm1c(EUCOMM)Wtsi
Emx1tm1(cre)Yql/Emx1+
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N
Cell Lines EPD0631_3_A09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btbd9tm1c(EUCOMM)Wtsi mutation (0 available); any Btbd9 mutation (40 available)
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit a 219% increase of slips in the beam walking test
• however, mice do not show a deficit in the rotarod test
• in the continuous open field test, mice show an increase in activity level during the light phase but not dark phase indicating a rest-phase specific motor restlessness
• however, mice exhibit a similar level of total distance traveled in a 30 min open field test as controls and similar wheel running activity during both the light and dark phase as in controls
• sleep analysis indicates an increased probability of waking in the light phase but not dark phase
• mice exhibit lower sensitivity to the heat stimuli than controls in the tail-flick test, indicating decreased thermal sensory perception

nervous system
• mice exhibit thinner cortical layers in the posterior primary motor cortex
• mice exhibit thinner cortical layers in both the anterior and posterior part of the primary somatosensory cortex representing the hindlimb

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
restless legs syndrome DOID:0050425 OMIM:PS102300
J:282582





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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory