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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trim58tm2313.1Arte
targeted mutation 2313.1, TaconicArtemis
MGI:6362941
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Trim58tm2313.1Arte/Trim58tm2313.1Arte
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6N MGI:6363314


Genotype
MGI:6363314
cn1
Allelic
Composition
Trim58tm2313.1Arte/Trim58tm2313.1Arte
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (10 available); any Lyz2 mutation (15 available)
Trim58tm2313.1Arte mutation (0 available); any Trim58 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mice show increased susceptibility to DSS-induced colitis, showing increased weight loss, decrease in colon length, rapid mucosal damage with greater ulcer formations and frequent transmural inflammatory cell infiltrates consisting mostly of CD11b+ myeloid cells
• however, colons show comparable improvement with signs of intestinal epithelial cell regeneration and tissue repair as in wild-type mice

immune system
• mice show increased susceptibility to DSS-induced colitis, showing increased weight loss, decrease in colon length, rapid mucosal damage with greater ulcer formations and frequent transmural inflammatory cell infiltrates consisting mostly of CD11b+ myeloid cells
• however, colons show comparable improvement with signs of intestinal epithelial cell regeneration and tissue repair as in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory