Phenotypes associated with this allele

• Allele Symbol: Rdh7^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6362645
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rdh7^tm1c(KOMP)Wtsi/Rdh7^tm1c(KOMP)Wtsi Tg(RARE-Hspa1b/lacZ)12Jrt/0 Tg(Vil1-cre)997Gum/0	involves: C57BL/6J * C57BL/6N * CD-1 * SJL	MGI:6362927

Genotype
MGI:6362927

cn1

• Allelic Composition: Rdh7^{tm1c(KOMP)Wtsi}/Rdh7^{tm1c(KOMP)Wtsi}; Tg(RARE-Hspa1b/lacZ)12Jrt/0; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:279231 )

N • mice exhibit normal numbers of TH17 and T regulatory cells in the small intestine and colon

decreased lymphocyte cell number ( J:279231 )

• reduced NCR+ IL22-producing RORgammat+ innate lymphoid cells (ILC3s) in the small intestinal lamina propria

• however, the number of NCR- ILC3s and lymphoid tissue inducer (LTi) cells are normal

decreased susceptibility to bacterial infection ( J:279231 )

• enhanced resistance to colonization by gut pathogens (C. rodentium and S. Typhimurium) with reduced colony forming units in the feces and spleen

• however, IL22 supplementation reverses resistance

hematopoietic system

decreased lymphocyte cell number ( J:279231 )

• reduced NCR+ IL22-producing RORgammat+ innate lymphoid cells (ILC3s) in the small intestinal lamina propria

• however, the number of NCR- ILC3s and lymphoid tissue inducer (LTi) cells are normal