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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pcbp2tm1.2Salr
targeted mutation 1.2, Stephen A Liebhaber
MGI:5908914
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pcbp2tm1.2Salr/Pcbp2tm1.2Salr involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:5909012
ht2
Pcbp2tm1.2Salr/Pcbp2+ involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:5909013
cx3
Pcbp1em2Salr/Pcbp1+
Pcbp2tm1.2Salr/Pcbp2+
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:5909014


Genotype
MGI:5909012
hm1
Allelic
Composition
Pcbp2tm1.2Salr/Pcbp2tm1.2Salr
Genetic
Background
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcbp2tm1.2Salr mutation (0 available); any Pcbp2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are present at 7 days of life
• mice die between E12.5 and E14.5 to E15.5

cardiovascular system
• large focal at E13.5 in most mice
• microhemorrhage in the minority of E12.5 embryos

homeostasis/metabolism
• at E13.5 in most mice




Genotype
MGI:5909013
ht2
Allelic
Composition
Pcbp2tm1.2Salr/Pcbp2+
Genetic
Background
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcbp2tm1.2Salr mutation (0 available); any Pcbp2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increase in immature (S1) cells with a decrease in more mature (S3 and S4/S5) erythroblasts
• however, there is no impact on the number of red blood cells
• trend toward lower mean platelet counts

growth/size/body
• prior to weaning and through adulthood in female and male mice
• however, crown-rump length and placental diameter are normal




Genotype
MGI:5909014
cx3
Allelic
Composition
Pcbp1em2Salr/Pcbp1+
Pcbp2tm1.2Salr/Pcbp2+
Genetic
Background
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcbp1em2Salr mutation (0 available); any Pcbp1 mutation (26 available)
Pcbp2tm1.2Salr mutation (0 available); any Pcbp2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 1 mouse survived beyond the first week of life
• fewer than expected mice are born alive

growth/size/body
• in surviving mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory