Pcbp1^em2Salr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pcbp1^em2Salr
• Name: poly(rC) binding protein 1; endonuclease-mediated mutation 2, Stephen A Liebhaber
• MGI ID: MGI:5908909
• Gene: Pcbp1 Location: Chr6:86501462-86503171 bp, - strand Genetic Position: Chr6, 37.72 cM, cytoband D1
• Alliance: Pcbp1^em2Salr page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN technology targeting the translation start site generated an 11 bp deletion including the ATG. Western blot analysis confirmed a greater than 50% reduction of protein expression in heterozygotes. (J:235912)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcbp1 Mutation: 32 strains or lines available

References

• Original: J:235912 Ghanem LR, et al., The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Mol Cell Biol. 2015 Nov 02;36(2):304-19
• All: 1 reference(s)