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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pltptm2.1Jia
targeted mutation 2.1, Xian-cheng Jiang
MGI:5825236
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Pltptm2.1Jia/Pltptm2.1Jia involves: C57BL/6J MGI:5902567


Genotype
MGI:5902567
cn1
Allelic
Composition
Pltptm2.1Jia/Pltptm2.1Jia
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pltptm2.1Jia mutation (0 available); any Pltp mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• hepatocytes from mice injected with an adenovirus-associated virus expressing cre recombinase (AAV-cre) driven by the liver-specific thyroxine binding globulin promoter show reduced nascent HDL production
• AAV-cre treated mice exhibit a 29% decrease in non-HDL cholesterol
• AAV-cre treated mice exhibit a 60% decrease of total apoB and 35% decrease of apoAI plasma levels
• AAV-cre treated mice exhibit 21% decrease in plasma cholesterol levels
• AAV-cre treated mice exhibit a 20% decrease in HDL cholesterol
• AAV-cre treated mice show a reduction in particle numbers in HDL, however no particle size difference is seen
• AAV-cre treated mice exhibit a 17% decrease in HDL phospholipid
• AAV-cre treated mice exhibit a 35% decrease in non-HDL phospholipid levels
• AAV-cre treated mice exhibit a 22% decrease in plasma phospholipid levels
• AAV-cre treated mice exhibit a 32% decrease in plasma triglyceride levels

cellular
• hepatocytes from mice injected with an adenovirus-associated virus expressing cre recombinase (AAV-cre) driven by the liver-specific thyroxine binding globulin promoter show reduced nascent HDL production





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory