Phenotypes associated with this allele

• Allele Symbol: Pltp^tm2.1Jia
• Allele Name: targeted mutation 2.1, Xian-cheng Jiang
• Allele ID: MGI:5825236
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pltp^tm2.1Jia/Pltp^tm2.1Jia	involves: C57BL/6J	MGI:5902567

Genotype
MGI:5902567

cn1

• Allelic Composition: Pltp^tm2.1Jia/Pltp^tm2.1Jia
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cellular cholesterol metabolism ( J:239143 )

• hepatocytes from mice injected with an adenovirus-associated virus expressing cre recombinase (AAV-cre) driven by the liver-specific thyroxine binding globulin promoter show reduced nascent HDL production

abnormal circulating non-HDL cholesterol level ( J:239143 )

• AAV-cre treated mice exhibit a 29% decrease in non-HDL cholesterol

• AAV-cre treated mice exhibit a 60% decrease of total apoB and 35% decrease of apoAI plasma levels

decreased circulating cholesterol level ( J:239143 )

• AAV-cre treated mice exhibit 21% decrease in plasma cholesterol levels

decreased circulating HDL cholesterol level ( J:239143 )

• AAV-cre treated mice exhibit a 20% decrease in HDL cholesterol

• AAV-cre treated mice show a reduction in particle numbers in HDL, however no particle size difference is seen

decreased circulating HDL phospholipid level ( J:239143 )

• AAV-cre treated mice exhibit a 17% decrease in HDL phospholipid

decreased circulating non-HDL phospholipid level ( J:239143 )

• AAV-cre treated mice exhibit a 35% decrease in non-HDL phospholipid levels

decreased circulating phospholipid level ( J:239143 )

• AAV-cre treated mice exhibit a 22% decrease in plasma phospholipid levels

decreased circulating triglyceride level ( J:239143 )

• AAV-cre treated mice exhibit a 32% decrease in plasma triglyceride levels

cellular

abnormal cellular cholesterol metabolism ( J:239143 )

• hepatocytes from mice injected with an adenovirus-associated virus expressing cre recombinase (AAV-cre) driven by the liver-specific thyroxine binding globulin promoter show reduced nascent HDL production