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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mogat1tm1Far
targeted mutation 1, Bob Farese
MGI:5785005
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mogat1tm1Far/Mogat1tm1Far involves: 129S4/SvJae MGI:5898247
cx2
Lepob/Lepob
Mogat1tm1Far/Mogat1tm1Far
involves: 129S4/SvJae MGI:5898250
cx3
Agpat2tm1Garg/Agpat2tm1Garg
Mogat1tm1Far/Mogat1tm1Far
involves: 129S4/SvJae * 129S6/SvEvTac MGI:5898249


Genotype
MGI:5898247
hm1
Allelic
Composition
Mogat1tm1Far/Mogat1tm1Far
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mogat1tm1Far mutation (1 available); any Mogat1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in female mice
• however, male mice exhibit normal weight

homeostasis/metabolism
N
• mice exhibit normal plasma triglyceride levels and consumption of oxygen and carbon dioxide

liver/biliary system
N
• male and female mice exhibit normal liver triglyceride levels




Genotype
MGI:5898250
cx2
Allelic
Composition
Lepob/Lepob
Mogat1tm1Far/Mogat1tm1Far
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (5 available); any Lep mutation (16 available)
Mogat1tm1Far mutation (1 available); any Mogat1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice exhibit normal metabolism
• in female mice as in Lepob homozygotes
• in a meal tolerance test
• as in Lepob homozygotes
• in female mice as in Lepob homozygotes
• as in Lepob homozygotes
• but not as much as in female mice as in Lepob homozygotes

liver/biliary system
• but not as much as in female mice as in Lepob homozygotes




Genotype
MGI:5898249
cx3
Allelic
Composition
Agpat2tm1Garg/Agpat2tm1Garg
Mogat1tm1Far/Mogat1tm1Far
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agpat2tm1Garg mutation (0 available); any Agpat2 mutation (5 available)
Mogat1tm1Far mutation (1 available); any Mogat1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice exhibit normal plasma triglyceride, cholesterol levels, creatine kinase and creatinine level, and consumption of oxygen and carbon dioxide
• in female, but not male, mice as in Agpat2tm1Garg homozygotes
• during an oral glucose tolerance test whether fasted or not
• male, but not female, mice exhibit increased glucose clearance compared with wild-type mice
• hyperinsulinic-insulin resistant whether fasted or not
• however, mice exhibit normal glucose tolerance and normal insulin sensitivity in a meal tolerance test
• in female and male mice as in Agpat2tm1Garg homozygotes

liver/biliary system
• in female and male mice at 16 weeks as in Agpat2tm1Garg homozygotes
• in female and male mice as in Agpat2tm1Garg homozygotes

behavior/neurological
• in male and female mice as in Agpat2tm1Garg homozygotes
• in female, but not male, mice

growth/size/body
• in female and male mice as in Agpat2tm1Garg homozygotes
• in female and male mice at 16 weeks as in Agpat2tm1Garg homozygotes





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last database update
01/19/2021
MGI 6.16
The Jackson Laboratory