Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation
(0 available);
any
Omp mutation
(27 available)
Pgrmc1tm1.1Jjp mutation
(0 available);
any
Pgrmc1 mutation
(10 available)
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behavior/neurological
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• female mice exhibit constant attraction behavior to recombinant major urinary proteins (rMUPs), in both estrus and diestrus unlike wild-type mice
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nervous system
N |
• vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4
• VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus
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taste/olfaction
N |
• vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4
• VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc1tm1.1Jjp mutation
(0 available);
any
Pgrmc1 mutation
(10 available)
Pgrmc2tm1.1Jjp mutation
(0 available);
any
Pgrmc2 mutation
(6 available)
Pgrtm2(cre)Lyd mutation
(0 available);
any
Pgr mutation
(73 available)
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mortality/aging
reproductive system
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• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months
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• breakdown of basement membrane and disruption of epithelial-stromal interface
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• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
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• enlarged amorphic and cystic glands characteristic of aged endometrium
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• female mice have fewer pups per litter and fewer litters per female compared with control mice
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• fewer pups per litter and fewer litters per female
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endocrine/exocrine glands
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• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
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• enlarged amorphic and cystic glands characteristic of aged endometrium
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growth/size/body
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• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc1tm1.1Jjp mutation
(0 available);
any
Pgrmc1 mutation
(10 available)
Pgrmc2tm1.1Jjp mutation
(0 available);
any
Pgrmc2 mutation
(6 available)
Pgrtm2(cre)Lyd mutation
(0 available);
any
Pgr mutation
(73 available)
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endocrine/exocrine glands
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• enlarged amorphic and cystic glands characteristic of aged endometrium
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reproductive system
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• enlarged amorphic and cystic glands characteristic of aged endometrium
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