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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• loss of hair pigmentation in 5 months with irregular deposition of pigment
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• hyperpigmentation at 3 weeks of age that progresses to extremely dark skin by 3 months
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• the trunk dermis contains abundant melanin
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• decreased
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• increased
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• hyperpigmentation within the cranium due to melanocyte overgrowth within the leptomeninges
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• extensive overgrowth of pigmented cells that fills the paces in the cochlea and vestibular system
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• rare melanocytic lesions on the trunk and head
• pigment cells invade the orbital-frontal cortex, cerebellum and medulla oblongata
• one mouse exhibited a large darkly pigmented lesion on the brain surface
• heavily pigmented spinal cord and meninges
• extensive overgrowth of pigmented cells that fills the paces in the cochlea and vestibular system
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• hyperpigmentation at 3 weeks of age that progresses to extremely dark skin by 3 months
• hyperpigmentation extends into the hypodermis
• the trunk dermis contains abundant melanin
• the hair follicle bulbs of the trunk and tail develop dark, ectopic pigmentation
• hyperpigmentation within the cranium due to melanocyte overgrowth within the leptomeninges
• heavily pigmented lymph nodes in the neck and trunk
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• early stages of tail darkening
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• 100% penetrance of uveal melanoma at 3 months
• older mice exhibit bigger tumors that largely fill the vitreous space
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• young mice exhibit a mass forming at the anterior of the eye
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• in older mice
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• young mice exhibit thickened uveal tract (iris, ciliary body and choroid) compared with control mice
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• increased
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• flipping onto the back beginning between month 1 and 3
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• beginning between month 1 and 3
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• at 3 months, most mice exhibit pigmented lesions within the lungs with intravasation into the blood vessels
• heavily pigmented lymph nodes in the neck and trunk
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• 100% penetrance of uveal melanoma at 3 months
• older mice exhibit bigger tumors that largely fill the vitreous space
|
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• more so than Tg(Mitf-cre)7114Gsb mice
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• heavily pigmented and enlarged in the neck and trunk
|
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• loss of hair pigmentation in 5 months with irregular deposition of pigment
|
|
• separation of the dermis and epidermis at 3 weeks of age
|
|
• hyperpigmentation at 3 weeks of age that progresses to extremely dark skin by 3 months
|
|
• the trunk dermis contains abundant melanin
|
|
• decreased
|
|
• early stages of tail darkening
|
|
• early stages of tail darkening
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• heavily pigmented spinal cord and meninges
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| uveal melanoma | DOID:6039 |
OMIM:155720 OMIM:606660 OMIM:606661 |
J:225597 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when cultured on fibronectin-coated plates, inter-follicular epidermis melanocytes exhibit reversable increased survival compared with wild-type mice
• impaired melanocyte survival and production of long, breakable and fragmentable dendrites when co-cultured with inter-follicular epidermis
• however, melanocytes exhibit normal migration and extension/retraction of protrusions when co-cultured with inter-follicular epidermis
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• impaired proliferation when melanocytes are co-cultured with inter-follicular epidermis
|
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• impaired proliferation when melanocytes are co-cultured with inter-follicular epidermis
|
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• more dendritic morphology with increased protrusions per cell
• some cells in culture adopt a round shape unlike wild-type cells
• melanocytes grown with mouse embryonic fibroblasts exhibit larger and irregular shapes compared with wild-type cells
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|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at 5 weeks of age, mice exhibit fewer lacZ+ cells in tail scales compared with control mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at 3 weeks of age, the number of lacZ+ melanocytes in tail scales is normal
|
|
• in older mice, melanin content in the tail scales is reduced compared to in control mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• melanocytic hyperplasia in tamoxifen treated mice after 2 and 6.5 months
|
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• 2 months after tamoxifen treatment
|
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• 2 months after tamoxifen treatment
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| N |
• tamoxifen-treated mice do not exhibit any behavioral abnormalities
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in inter-follicular epidermis of tamoxifen-treated mice
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• in inter-follicular epidermis of tamoxifen-treated mice
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• in inter-follicular epidermis of tamoxifen-treated mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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