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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir182tm1.1Dgk
targeted mutation 1.1, David Kirsch
MGI:5702430
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir182tm1.1Dgk/Mir182tm1.1Dgk involves: 129/Sv * C57BL/6 MGI:5704431
cn2
 		Krastm4Tyj/Krastm4Tyj
Mir182tm1.1Dgk/Mir182tm1.1Dgk
Trp53tm1Brn/Trp53tm1Brn 		involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5704424
cn3
 		Krastm4Tyj/Krastm4Tyj
Mir182tm1.1Dgk/Mir182+
Trp53tm1Brn/Trp53tm1Brn 		involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5704427


Genotype
MGI:5704431
hm1
Allelic
Composition		 Mir182tm1.1Dgk/Mir182tm1.1Dgk
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir182tm1.1Dgk mutation (1 available); any Mir182 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:217635 )
• mice are viable and fertile




Genotype
MGI:5704424
cn2
Allelic
Composition		 Krastm4Tyj/Krastm4Tyj
Mir182tm1.1Dgk/Mir182tm1.1Dgk
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Mir182tm1.1Dgk mutation (1 available); any Mir182 mutation (8 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:217635 )
• 13% of mice develop lung metastases within 6 months following amputation of limb injected with cre-expressing adenovirus
• in the absence of the Mir18tm1.1Dgk allele, 43% of mice develop lung metastases
• number of metastatic nodules and metastatic burden in the lung are decreased compared to mice without the Mir18tm1.1Dgk allele




Genotype
MGI:5704427
cn3
Allelic
Composition		 Krastm4Tyj/Krastm4Tyj
Mir182tm1.1Dgk/Mir182+
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Mir182tm1.1Dgk mutation (1 available); any Mir182 mutation (8 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:217635 )
• 20% of mice develop lung metastases by 120 days following amputation of limb injected with cre-expressing adenovirus
• in the absence of the Mir18tm1.1Dgk allele, 43% of mice develop lung metastases
• number of metastatic nodules and metastatic burden in the lung are decreased compared to mice without the Mir18tm1.1Dgk allele




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory