Phenotypes associated with this allele

• Allele Symbol: Auts2^tm1.1Dare
• Allele Name: targeted mutation 1.1, Danny Reinberg
• Allele ID: MGI:5697527
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Auts2^tm1.1Dare/Auts2^tm1.1Dare Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:5697531
cn2	Auts2^tm1.1Dare/Auts2^+ Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:5697533

Genotype
MGI:5697531

cn1

• Allelic Composition: Auts2^tm1.1Dare/Auts2^tm1.1Dare; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased food intake ( J:217675 )

• knockouts showed a significantly smaller milk band at P1

impaired righting response ( J:217675 )

• knockout mice show impairment in righting reflex relative to wild type from P3-P9, whereas heterozygotes are not impaired

positive geotaxis ( J:217675 )

• knockout mice took significantly longer to orient their nose to an upward position (turn 180o and face upwards on a slanted platform)

decreased vocalization ( J:217675 )

• knockout mice show significantly less ultrasonic vocalizations (USVs) than wild type following maternal separation across the majority of developmental time points measured

growth/size/body

decreased body length ( J:217675 )

• a striking visual and quantitative reduction in the body length of the knockout mice is sen relative to control littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant intellectual developmental disorder		DOID:0060307	OMIM:PS156200	J:217675

Genotype
MGI:5697533

cn2

• Allelic Composition: Auts2^tm1.1Dare/Auts2⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

behavior/neurological

decreased vocalization ( J:217675 )

• heterozygous mice show significantly less ultrasonic vocalizations (USVs) than wild type following maternal separation across the majority of developmental time points measured

growth/size/body

decreased body length ( J:217675 )

• a reduction in the body length of the heterozygous mice is seen relative to controls but heterozygotes show an intermediate phenotype relative to knockout littermates