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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lrp4mdig-3J
malformed digits 3 Jackson
MGI:5688522
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lrp4mdig-3J/Lrp4mdig-3J B6.Cg-Lrp4mdig-3J/GrsrJ MGI:5688562


Genotype
MGI:5688562
hm1
Allelic
Composition
Lrp4mdig-3J/Lrp4mdig-3J
Genetic
Background
B6.Cg-Lrp4mdig-3J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4mdig-3J mutation (1 available); any Lrp4 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• homozygotes have shortened or fused digits on all four feet with some toes being both shortened and fused

skeleton
• the teeth require trimming when the homozygotes are young, but this need goes away as they mature

reproductive system
• some, but not all, homozygotes fail to breed

craniofacial
• the teeth require trimming when the homozygotes are young, but this need goes away as they mature

growth/size/body
• the teeth require trimming when the homozygotes are young, but this need goes away as they mature
• homoygotes are slightly smaller than normal littermates

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
sclerosteosis 2 DOID:0060757 OMIM:614305
J:224655





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory