Phenotypes associated with this allele

• Allele Symbol: Rasa1^tm2.1Pdk
• Allele Name: targeted mutation 2.1, Philip D King
• Allele ID: MGI:5661985
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasa1^tm2.1Pdk/Rasa1^tm2.1Pdk	involves: 129S6/SvEvTac * C57BL/6	MGI:5688690

Genotype
MGI:5688690

hm1

• Allelic Composition: Rasa1^tm2.1Pdk/Rasa1^tm2.1Pdk
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:216433 )

• embryonic lethality, with fewer than the expected numbers seen at E11 and no embryos seen at E13.5, however the expected numbers are seen at E9.5

growth/size/body

decreased embryo size ( J:216433 )

• embryos are smaller at E9.5 and appear less well developed

embryo

abnormal vitelline vasculature morphology ( J:216433 )

• no organized vascular networks are seen in the yolk sacs of E9.5 embryos and endothelial cells are in a honeycombed pattern

decreased embryo size ( J:216433 )

• embryos are smaller at E9.5 and appear less well developed

excessive folding of visceral yolk sac ( J:216433 )

• wrinkled yolk sac in E9.5 embryos

cardiovascular system

abnormal blood vessel morphology ( J:216433 )

• the blood vessel network is abnormal in E9.5 embryos

abnormal dorsal aorta morphology ( J:216433 )

• dorsal aorta shows a highly irregular shape, and is severely disrupted

abnormal intersomitic artery morphology ( J:216433 )

• intersegemental arteries are frequently irregular in shape

abnormal vitelline vasculature morphology ( J:216433 )

• no organized vascular networks are seen in the yolk sacs of E9.5 embryos and endothelial cells are in a honeycombed pattern

distended pericardium ( J:216433 )

• in E9.5 embryos