All Phenotypes Mirc1<tm2.1Aven> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mirc1^tm2.1Aven
targeted mutation 2.1, Andrea Ventura
MGI:5648458

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc1^tm2.1Aven/Mirc1^tm2.1Aven	B6.Cg-Mirc1^tm2.1Aven	MGI:5661549
hm2	Mirc1^tm2.1Aven/Mirc1^tm2.1Aven	involves: 129S4/SvJae * C57BL/6 * SJL/J	MGI:5661546
cx3	Mirc1^tm2.1Aven/Mirc1^tm2.1Aven Tg(ARR2/Pbsn-MYC)7Key/0	involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL/J	MGI:5662416
cx4	Mirc1^tm2.1Aven/Mirc1^tm2.1Aven Tg(IghMyc)22Bri/?	involves: 129S4/SvJae * C57BL/6 * SJL/J	MGI:5662410
cx5	Mirc1^tm2.1Aven/Mirc1⁺ Tg(IghMyc)22Bri/?	involves: 129S4/SvJae * C57BL/6 * SJL/J	MGI:5662414

Allelic Composition	Mirc1^tm2.1Aven/Mirc1^tm2.1Aven
Genetic Background	B6.Cg-Mirc1^tm2.1Aven

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1^tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:223213 )

• heterozygote x heterozygote matings produce 5% homozygotes rather than the expected 25%

skeleton

vertebral fusion ( J:223213 )

• 20% of mice exhibit vertebral fusion

Allelic Composition	Mirc1^tm2.1Aven/Mirc1^tm2.1Aven
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1^tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:223213 )

• decrease in total splenic B cells

decreased myeloid cell number ( J:223213 )

• decrease in total splenic myeloid cell (CD11b+) number

immune system

decreased B cell number ( J:223213 )

• decrease in total splenic B cells

Allelic Composition	Mirc1^tm2.1Aven/Mirc1^tm2.1Aven Tg(ARR2/Pbsn-MYC)7Key/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1^tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
Tg(ARR2/Pbsn-MYC)7Key mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small prostate gland ( J:223213 )

• prostate volume is reduced compared to Tg(ARR2/Pbsn-MYC)7Key alone

decreased prostate gland tumor incidence ( J:223213 )

• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

increased prostate gland adenocarcinoma incidence ( J:223213 )

• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

reproductive system

small prostate gland ( J:223213 )

• prostate volume is reduced compared to Tg(ARR2/Pbsn-MYC)7Key alone

increased prostate gland adenocarcinoma incidence ( J:223213 )

• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

neoplasm

decreased prostate gland tumor incidence ( J:223213 )

• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

increased prostate gland adenocarcinoma incidence ( J:223213 )

• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

Allelic Composition	Mirc1^tm2.1Aven/Mirc1^tm2.1Aven Tg(IghMyc)22Bri/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1^tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased B cell apoptosis ( J:223213 )

• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone

mortality/aging

abnormal survival ( J:223213 )

• increase in survival as compared to mice carrying Tg(IghMyc)22Bri alone and mice carrying Tg(IghMyc)22Bri and heterozygous for Mirc1^tm2.1Aven

hematopoietic system

increased B cell apoptosis ( J:223213 )

• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone

abnormal pre-B cell morphology ( J:223213 )

• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

immune system

increased B cell apoptosis ( J:223213 )

• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone

abnormal pre-B cell morphology ( J:223213 )

• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

neoplasm

increased B cell derived lymphoma incidence ( J:223213 )

• immunophenotype of B cell lymphomas is altered (increase in in IgM+ tumors) as compared to Tg(IghMyc)22Bri alone

increased tumor latency ( J:223213 )

• as compared to mice carrying only Tg(IghMyc)22Bri

Allelic Composition	Mirc1^tm2.1Aven/Mirc1⁺ Tg(IghMyc)22Bri/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1^tm2.1Aven mutation (1 available); any Mirc1 mutation (6 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:223213 )

• increase in survival as compared to mice carrying Tg(IghMyc)22Br

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