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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Camta1tm1.1Eno
targeted mutation 1.1, Eric N Olson
MGI:5637357
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Camta1tm1.1Eno/Camta1tm1.1Eno
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL MGI:5762853


Genotype
MGI:5762853
cn1
Allelic
Composition
Camta1tm1.1Eno/Camta1tm1.1Eno
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camta1tm1.1Eno mutation (0 available); any Camta1 mutation (7 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Degeneration of Purkinje cells and cerebellar atrophy in Camta1tm1.1Eno/Camta1tm1.1Eno Tg(Nes-cre)1Kln/0 mice

mortality/aging
N
• mice exhibit normal survival up to 1 year of age, unlike Camta1tm1.2Eno homozygotes

growth/size/body
• runting is seen in only a subset of mice and is less severe than in Camta1tm1.2Eno homozygotes

behavior/neurological
• severe ataxia by 6 weeks of age, as determined by several motor tasks and general observation
• fully penetrant at >3 months of age
• impaired motor performance on the accelerating rotarod and beam walk tests by 6 weeks of age
• by 3 months, loss of motor coordination is fully penetrant and more pronounced in the hindlimbs

nervous system
• Purkinje cells are reduced in size and disarrayed at 6 months of age
• severe loss of Purkinje cells at 3 months of age
• however, Purkinje cell number is normal at age 2-3 weeks of age
• significant decrease in the width of the cerebellar granular layer at 3 months of age
• significant decrease in the width of the cerebellar molecular layer at 3 months of age
• progressive cerebellar atrophy with significant reduction in cerebellar size at 3 months of age
• however, cerebellar architecture is normal at 2-3 weeks of age

reproductive system
• young mice breed at a reduced frequency





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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory