Phenotypes associated with this allele

• Allele Symbol: Ssr2^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637009
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ssr2^tm1b(EUCOMM)Wtsi/Ssr2^tm1b(EUCOMM)Wtsi	C57BL/6N-Ssr2^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5883886

Genotype
MGI:5883886

hm1

• Allelic Composition: Ssr2^{tm1b(EUCOMM)Wtsi}/Ssr2^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Ssr2^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0654_2_C10

Data Sources

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

interrupted aortic arch, type b ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

abnormal hepatic vein connection ( J:239583 )

DMDD

thin myocardium compact layer ( J:239583 )

DMDD

common truncal valve ( J:239583 )

DMDD

persistent truncus arteriosus ( J:239583 )

DMDD

double outlet right ventricle ( J:239583 )

DMDD

abnormal inferior vena cava valve morphology ( J:239583 )

DMDD

abnormal interatrial septum morphology ( J:239583 )

DMDD

abnormal atrioventricular septum morphology ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 , J:261316 )

DMDD (J:239583)

MGI (J:261316)

muscular ventricular septal defect ( J:239583 )

DMDD

abnormal pulmonary valve cusp morphology ( J:239583 )

DMDD

hemopericardium ( J:239583 )

DMDD

intracerebral hemorrhage ( J:239583 )

DMDD

craniofacial

basisphenoid bone foramen ( J:239583 )

DMDD

abnormal hyoid bone greater horn morphology ( J:239583 )

DMDD

embryo

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

abnormal Wolffian duct morphology ( J:239583 )

DMDD

endocrine/exocrine glands

abnormal thymus morphology ( J:239583 )

DMDD

growth/size/body

fetal growth retardation ( J:239583 )

DMDD

heterochrony ( J:239583 )

DMDD

hematopoietic system

abnormal thymus morphology ( J:239583 )

DMDD

homeostasis/metabolism

hemopericardium ( J:239583 )

DMDD

subcutaneous edema ( J:239583 )

DMDD

immune system

abnormal thymus morphology ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:261316 )

• lethality at P14, with viable fetuses at E14.5

muscle

thin myocardium compact layer ( J:239583 )

DMDD

abnormal eye muscle morphology ( J:239583 )

DMDD

abnormal diaphragm morphology ( J:239583 )

DMDD

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

abnormal digastric muscle morphology ( J:239583 )

DMDD

neoplasm

increased trigeminal neuroma incidence ( J:239583 )

DMDD

nervous system

intracerebral hemorrhage ( J:239583 )

DMDD

increased trigeminal neuroma incidence ( J:239583 )

DMDD

small superior cervical ganglion ( J:239583 )

DMDD

reduced sympathetic cervical ganglion size ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 , J:261316 )

DMDD (J:239583)

MGI (J:261316)

enlarged third ventricle ( J:239583 )

DMDD

dilated lateral ventricle ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

abnormal optic nerve morphology ( J:239583 )

DMDD

abnormal optic chiasm morphology ( J:239583 )

DMDD

respiratory system

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

abnormal digastric muscle morphology ( J:239583 )

DMDD

skeleton

basisphenoid bone foramen ( J:239583 )

DMDD

abnormal hyoid bone greater horn morphology ( J:239583 )

DMDD

scoliosis ( J:239583 )

DMDD

fusion of vertebral arches ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

abnormal optic nerve morphology ( J:239583 )

DMDD

abnormal optic chiasm morphology ( J:239583 )

DMDD

abnormal optic cup morphology ( J:239583 )

DMDD

abnormal optic stalk morphology ( J:239583 )

DMDD