All Phenotypes Tg(HLA-DRA,HLA-DRB5*0101)loKito MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(HLA-DRA,HLA-DRB5*0101)loKito
transgene insertion lo, Kouichi Ito
MGI:5635431

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2^dlAb1-Ea/H2^dlAb1-Ea Rag1^tm1Mom/Rag1^tm1Mom Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:5635503
cx2	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * C57BL/6	MGI:5635488

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Rag1^tm1Mom/Rag1^tm1Mom Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (280 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (120 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

brain inflammation ( J:189816 )

• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age

nervous system

brain inflammation ( J:189816 )

• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (280 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:189816 )

• mice rarely exhibit experimental autoimmune encephalitis when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 47% of mice

brain inflammation ( J:189816 )

• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age

nervous system

brain inflammation ( J:189816 )

• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age

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