Phenotypes associated with this allele

• Allele Symbol: Prlh^tm2Smln
• Allele Name: targeted mutation 2, Simon M Luckman
• Allele ID: MGI:5634278
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prlh^tm2Smln/Prlh^tm2Smln	involves: C57BL/6J	MGI:5634285
cn2	Prlh^tm2Smln/Prlh^tm2Smln Tg(Nes-cre)1Kln/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:5634286
cn3	Prlh^tm2Smln/Prlh^tm2Smln 7630403G23Rik^Tg(Th-cre)1Tmd/7630403G23Rik^+	involves: C57BL/6 * C57BL/6J * SJL	MGI:5634287

Genotype
MGI:5634285

hm1

• Allelic Composition: Prlh^tm2Smln/Prlh^tm2Smln
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:215557 )

N • mice exhibit normal energy expenditure

increased susceptibility to diet-induced obesity ( J:215557 )

• when fed a high-energy diet

hyperglycemia ( J:215557 )

• in fed and fasted states at 16 weeks

• however, levels are normal at 6-8 weeks

increased circulating insulin level ( J:215557 )

• at 16 weeks

increased circulating leptin level ( J:215557 )

• at 16, but not 6, weeks

decreased core body temperature ( J:215557 )

abnormal body temperature homeostasis ( J:215557 )

• mice treated with leptin fails to increase core body temperature unlike wild-type mice

abnormal response/metabolism to endogenous compounds ( J:215557 )

• mice treated with leptin fails to increase core body temperature unlike wild-type mice

• mice treated with leptin or Cck fail to exhibit a change in normal, night-time food intake compared with wild-type mice

growth/size/body

increased body weight ( J:215557 )

• in female and male mice at 8 to 9 weeks

obese ( J:215557 )

• at 12 weeks

increased susceptibility to diet-induced obesity ( J:215557 )

• when fed a high-energy diet

adipose tissue

increased subcutaneous adipose tissue amount ( J:215557 )

• at 16 weeks

increased total body fat amount ( J:215557 )

• at 18 weeks

increased epididymal fat pad weight ( J:215557 )

• at 16 weeks

behavior/neurological

increased food intake ( J:215557 )

• at 13 and 16 weeks

• however, food intake is normal at 7 and 10 weeks

integument

increased subcutaneous adipose tissue amount ( J:215557 )

• at 16 weeks

Genotype
MGI:5634286

cn2

• Allelic Composition: Prlh^tm2Smln/Prlh^tm2Smln; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

behavior/neurological

behavior/neurological phenotype ( J:215557 )

N • mice exhibit normal food intake

growth/size/body

growth/size/body region phenotype ( J:215557 )

N • mice exhibit normal body weight

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:215557 )

N • mice exhibit normal response to leptin and Cck

Genotype
MGI:5634287

cn3

• Allelic Composition: Prlh^tm2Smln/Prlh^tm2Smln; 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

growth/size/body

growth/size/body region phenotype ( J:215557 )

N • mice exhibit normal body weight

homeostasis/metabolism

abnormal body temperature homeostasis ( J:215557 )

• mice treated with leptin fails to increase core body temperature unlike wild-type mice

abnormal response/metabolism to endogenous compounds ( J:215557 )

• mice treated with leptin fails to increase core body temperature unlike wild-type mice

• mice treated with leptin fail to exhibit a change in normal, night-time food intake compared with wild-type mice

• however, mice treated with Cck exhibit a suppression in food intake