Phenotypes associated with this allele

• Allele Symbol: Cnr1^tm1.1Kpm
• Allele Name: targeted mutation 1.1, Ken Mackie
• Allele ID: MGI:5607776
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnr1^tm1.1Kpm/Cnr1^tm1.1Kpm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5607777

Genotype
MGI:5607777

hm1

• Allelic Composition: Cnr1^tm1.1Kpm/Cnr1^tm1.1Kpm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:208116 )

♂ • levels of the endocannabinoid, 2-arachidonoyl glycerol, are decreased in the cortex, but not in the striatum, hippocampus, cerebellum, midbrain, or forebrain

abnormal neuron physiology ( J:208116 )

♂ • cultured hippocampal neurons exhibit enhanced depolarization-induced suppression of excitation and desensitize more slowly

♂ • cultured hippocampal neurons treated with the Cnr1 (CB1R) agonist WIN55212-2 are only partially desensitized, indicating reduced agonist-mediated desensitization

abnormal synaptic plasticity ( J:208116 )

♂ • cultured hippocampal neurons show enhanced endocannabinoid-mediated synaptic plasticity

behavior/neurological

increased behavioral withdrawal response ( J:208116 )

♂ • mice show enhanced cannabinoid dependence, with mice showing more withdrawal-induced paw tremors, jumps, and diarrhea events than controls

increased chemically-elicited antinociception ( J:208116 )

♂ • mice show enhanced antinociceptive responses to delta-9-tetrahydrocannabinol (delta⁹-THC), N-arachidonoyl ethanolamine anandamide (AEA) or the monoacylglycerol lipase inhibitor, JZL195, indicating enhanced sensitivity to endocannabinoids

♂ • mice show delayed tolerance to the aninociceptive effects of delta⁹-THC

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:208116 )

♂ • mice are more sensitive to delta-9-tetrahydrocannabinol (delta⁹-THC), showing enhanced antinociceptive and hypothermic responses, have delayed tolerance to delta⁹-THC, and show increased dependence for delta⁹-THC

♂ • mice show increased responses (antinociceptive and hypothermic) to elevated levels of endogenous cannabinoids