Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shcbp1tm1c(EUCOMM)Wtsi mutation
(1 available);
any
Shcbp1 mutation
(42 available)
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normal phenotype
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• mice are viable and fertile
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shcbp1tm1c(EUCOMM)Wtsi mutation
(1 available);
any
Shcbp1 mutation
(42 available)
Tg(Lck-cre)1Cwi mutation
(3 available)
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immune system
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N |
• in 2 week old mice that are not injected with MOG peptide, T cell development is normal
• the fraction of absolute numbers of CD4+ and CD8+ T cells in spleen and lymph nodes is similar to controls
• percentages and numbers of thymic compartment subsets in 4-6 week old mice are similar to controls
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• reduced disease severity is observed in mice injected with MOG35-55 peptide as compared to MOG-injected wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1(cre)Thr mutation
(0 available);
any
Rag1 mutation
(120 available)
Shcbp1tm1c(EUCOMM)Wtsi mutation
(1 available);
any
Shcbp1 mutation
(42 available)
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immune system
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N |
• T cell development appears normal in 2 week old mice
• fraction of absolute numbers of CD4+ and CD8+ T cells in spleen and lymph nodes is similar to controls
• numbers and percentages of thymic compartment subsets in 4-6 week old mice are similar to controls
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Analysis Tools