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Allele Symbol Allele Name Allele ID |
Tg(H2-K-IL6)2Srj transgene insertion 2, Stefan Rose-John MGI:5582513 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal spleen and lymph node size, normal IgG levels and do not show hyperplastic germinal centers, extramedullary hematopoiesis, or plasmacytosis in lymphoid tissues at 4-5 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | viral infectious disease | DOID:934 | J:185153 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 15 week old mice exhibit enlarged spleen
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• 28% of mice exhibit multicentric Castleman disease-like changes
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• 32% of mice exhibit increased extramedullary hematopoiesis
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• elevation in numbers of megakaryocytes in the spleen of 15 week old mice
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• increase in granulocytopoiesis in the spleen in 15 week old mice
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• 44% of mice exhibit plasmacytosis in the red pulp of the spleen
• massive accumulations of plasma cells in peripheral lymph nodes
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• red pulp of spleen shows increased proliferation
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• hyperplastic germinal centers in 15 week old mice
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• 4-fold elevation in serum levels of IgG
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• 15 week old mice exhibit enlarged spleen
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• increase in granulocytopoiesis in the spleen in 15 week old mice
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• 44% of mice exhibit plasmacytosis in the red pulp of the spleen
• massive accumulations of plasma cells in peripheral lymph nodes
|
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• red pulp of spleen shows increased proliferation
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• hyperplastic germinal centers in 15 week old mice
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• 4-fold elevation in serum levels of IgG
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• enlarged B-cell follicles in peripheral and deep abdominal lymph nodes that contain hyperplastic germinal centers and vascular proliferation and massive accumulations of plasma cells
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• hyperplastic germinal centers in 15 week old mice
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• 15 week old mice exhibit enlarged lymph nodes
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• 15 week old mice exhibit enlarged spleen
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| viral infectious disease | DOID:934 | J:185153 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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