Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo10m1J mutation
(1 available);
any
Myo10 mutation
(609 available)
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vision/eye
integument
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• homozygotes have a white belly spot and, more rarely, a white spot on the back of an otherwise black coat
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• homozygotes often have irregular regions of diminished pigment on the tail
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pigmentation
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• homozygotes have a white belly spot and, more rarely, a white spot on the back of an otherwise black coat
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• homozygotes often have irregular regions of diminished pigment on the tail
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limbs/digits/tail
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• homozygotes often have irregular regions of diminished pigment on the tail
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• fused digits on either or both of the front feet, but not the hind feet
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growth/size/body
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• slightly smaller than normal
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skeleton
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo10m1J mutation
(1 available);
any
Myo10 mutation
(609 available)
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mortality/aging
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• less than half of homozygotes obtained from heterozygous matings survived birth; these were able to feed, develop into adults, and mate successfully
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• although homozygotes obtained from heterozygous matings were present at normal Mendelian ratios at E12.5-E17.5, homozygous mutant pups were obtained at less than half the expected number, with 14 of 174 (8%) being mutant pups versus 48 of 174 (28%) wild-type pups; fetuses undergoing resorption were also observed
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growth/size/body
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• 9% of embryos exhibited gross developmental defects such as very small size
• embryos were slightly smaller than controls even in the absence of exencephaly or other major defects
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• at P21 and P28, the average body weight was slightly smaller than that of wild-type and heterozygous controls
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nervous system
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• 18% of embryos exhibited craniorachischisis
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• exencephalic embryos showed absence of a cranium and gross defects in brain morphology
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• 73% of embryos obtained from heterozygous matings exhibited exencephaly
• 7 of the eight E15.5 embryos obtained from a homozygous mating had exencephaly, including one that also had omphalocele
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craniofacial
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• exencephalic embryos showed absence of a cranium and gross defects in brain morphology
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vision/eye
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• at E16.5, eyes exhibited defects in lens formation, often associated with persistent hyaloid vasculature
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• at E16.5, some eyes failed to undergo eyelid closure; failure of or delayed eyelid closure was observed both in exencephalic and non-exencephalic embryos
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• all 5 of the homozygotes whose eyes were dissected at 6 weeks showed persistent hyaloid vasculature that was pigmented and present bilaterally
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• 3 of 14 pups showed severe microphthalmia
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• 1 of 14 pups showed anophthalmia
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cardiovascular system
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• 64% of homozygous embryos from heterozygous matings had blood in the amniotic fluid
• all eight E15.5 embryos obtained from a homozygous mating exhibited blood in the amniotic sac
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pigmentation
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• 14 of 14 pups had a white belly spot and 4 of 14 also had a white spot on the back
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• all (14 of 14) pups showed a white belly spot
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limbs/digits/tail
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• 6 of 14 pups showed webbed digits on one or both forelimbs
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embryo
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• 9% of embryos exhibited gross developmental defects such as very small size
• embryos were slightly smaller than controls even in the absence of exencephaly or other major defects
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• 18% of embryos exhibited craniorachischisis
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integument
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• 14 of 14 pups had a white belly spot and 4 of 14 also had a white spot on the back
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• all (14 of 14) pups showed a white belly spot
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skeleton
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• exencephalic embryos showed absence of a cranium and gross defects in brain morphology
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liver/biliary system
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• 1 of the eight E15.5 embryos obtained from a homozygous mating was very small and appeared to lack a liver
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behavior/neurological
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• young adult homozygotes did not display obvious circling or shaking and showed a normal Preyer reflex
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